The core message of our recent report (1) is that nanomolar concentrations of cyanide increase O₂ consumption rate (OCR) and Complex IV (CcOX) activity and elevate adenosine triphosphate (ATP) levels in intact human cells (1). This effect—directionally opposite of the well-known inhibitory effect that cyanide exerts at higher concentrations—was demonstrated using several independent methods, including extracellular flux analysis and a fluorescent ATP:adenosine diphosphate biosensor (1). While preparing a review on cyanide’s cellular effects (2) we became aware of an earlier study, which, independently from us, also observed that nanomolar concentrations of cyanide increase OCR in rat brain endothelial cells (3).

中文翻译：

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对 Gamogante 等人的回复：低氰化物对 O2 消耗的影响最好在生理系统而非还原系统中观察到 [生物科学]

我们最近报告 ( 1 ) 的核心信息是，纳摩尔浓度的氰化物可提高完整人体细胞中的 O ₂消耗率 (OCR) 和复合物 IV (CcOX) 活性，并提高三磷酸腺苷 (ATP) 水平 ( 1 )。这种效应——与众所周知的氰化物在较高浓度下发挥的抑制效应相反——通过几种独立的方法得到证实，包括细胞外通量分析和荧光 ATP：二磷酸腺苷生物传感器 ( 1 )。在准备审查氰化物的细胞作用时（2) 我们注意到了一项较早的研究，该研究独立于我们，还观察到纳摩尔浓度的氰化物会增加大鼠脑内皮细胞中的 OCR ( 3 )。