Metabolic diseases are common worldwide and include diseases of overnutrition, such as obesity, or undernutrition, such as kwashiorkor. Both the immune system and the microbiota contribute to a variety of metabolic diseases; however, these two processes have largely been studied independently of one another in this context. The gastrointestinal system houses the greatest density of microbes but also houses one of the largest collections of immune molecules, especially Abs. The IgA isotype dominates the Ab landscape at mucosal sites, and a number of studies have demonstrated the importance of this Ab to the stability of the microbiota. In this article, we review the literature that demonstrates how homeostatic Ab responses control microbiota composition and function to influence metabolic disease. We propose that many metabolic diseases may arise from disruptions to homeostatic immune control of gut commensals and that further understanding this interaction can offer a novel opportunity for therapeutic interventions.

代谢性疾病在世界范围内很常见，包括营养过剩的疾病，如肥胖症，或营养不良的疾病，如 kwashiorkor。免疫系统和微生物群都会导致多种代谢疾病；然而，在这方面，这两个过程在很大程度上是相互独立研究的。胃肠系统拥有最大密度的微生物，但也拥有最大的免疫分子集合之一，尤其是 Abs。IgA 同种型在粘膜位点的 Ab 景观中占主导地位，许多研究已经证明了这种 Ab 对微生物群稳定性的重要性。在本文中，我们回顾了证明稳态抗体反应如何控制微生物群组成和功能以影响代谢疾病的文献。