The role of progesterone-induced blocking factor (PIBF)-mediated Th1/Th2 balance in delivery outcomes of in vitro fertilization and embryo transfer (IVF-ET) has not been fully elucidated. In this study, 73 infertile women with successful IVF-ET were enrolled (16 fetal arrests and 57 live births). PIBF and IL-4 levels were significantly lower in the fetal arrest group than in the live birth group (p < 0.05). TNF-α level and Th1/Th2 ratios were significantly higher in the fetal arrest group than in the live birth group (p < 0.05). High TNF-α level and Th1/Th2 ratios were risk factors for fetal arrest, whereas increased PIBF and IL-4 levels were protective factors (P < 0.05). Increased TNF-α/IL-4 exhibited relatively strong predictive value for fetal arrest (AUC, 0.855; sensitivity, 93.8%; specificity, 71.9%). In summary, the PIBF-mediated Th1/Th2 balance is closely correlated with delivery outcomes of IVF-ET. TNF-α/IL-4 may be a predictive marker of fetal arrest.

孕酮诱导阻断因子 (PIBF) 介导的 Th1/Th2 平衡在体外受精和胚胎移植 (IVF-ET) 分娩结果中的作用尚未完全阐明。在这项研究中，招募了 73 名成功进行 IVF-ET 的不孕妇女（16 名胎儿骤停和 57 名活产）。胎儿骤停组的 PIBF 和 IL-4 水平显着低于活产组（p  < 0.05）。胎儿骤停组的 TNF-α 水平和 Th1/Th2 比值显着高于活产组（p < 0.05）。高 TNF-α 水平和 Th1/Th2 比值是胎儿骤停的危险因素，而 PIBF 和 IL-4 水平升高是保护因素（P < 0.05)。增加的 TNF-α/IL-4 显示出相对较强的胎儿骤停预测价值（AUC，0.855；敏感性，93.8%；特异性，71.9%）。总之，PIBF 介导的 Th1/Th2 平衡与 IVF-ET 的分娩结果密切相关。TNF-α/IL-4 可能是胎儿骤停的预测标志物。