Contaminants of emerging concern (CEC) are a broad suite of chemicals commonly found in the environment, aquatic organisms and even drinking water. They include pharmaceuticals, personal care products, industrial chemicals and compounds added to consumer products. The CEC ammonium 2,3,3,3-tetrafluoro-2-heptafluoropropoxy propanoic acid, which is more commonly known as generic name GenX, is a replacement of common processing aid longer chain perfluorinated compounds (PFAS) due to a manufacturing shift in 2002 following the EPA stewardship program of 2015/16 in USA (USEPA, 2006). However, recently reported in North Carolina drinking water, GenX raising concerns about its accumulation in aquatic organisms, both wild and cultured, which could be a pathway for human exposure. To examine GenX accumulation and potential for human exposure, tilapia (Oreochromis mossambicus) fingerlings were dosed with GenX for up to 96 h in fresh (0 ppt) or brackish (16 ppt) water to determine uptake and bioconcentration. Depuration values were also determined after a 96 h exposure followed by 96 h without exposure. Bioconcentration was in decreasing order of plasma > liver > carcass > muscle, with higher distribution to liver followed by carcass and muscle. Muscle was found to have the highest half-life (1278 h) followed by carcass (532 h), plasma (106 h), and liver (152 h). The rate of uptake and depuration was positively affected by the salinity. As bioconcentration in all tissues increased with increasing salinity, this may raise concern for marine organisms and human exposure.

新出现的污染物 (CEC) 是一系列广泛存在于环境、水生生物甚至饮用水中的化学物质。它们包括药品、个人护理产品、工业化学品和添加到消费品中的化合物。CEC 铵 2,3,3,3-四氟-2-七氟丙氧基丙酸，更常被称为通用名称 GenX，由于 2002 年的生产转移，它是普通加工助剂长链全氟化合物 (PFAS) 的替代品遵循美国环保署 2015/16 年的管理计划（美国环保署，2006 年）。然而，最近在北卡罗来纳州的饮用水中报道，GenX 引起了人们对其在野生和养殖水生生物中积累的担忧，这可能是人类接触的途径。为了检查 GenX 的积累和人类暴露的潜力，罗非鱼 (Oreochromis mossambicus)鱼种在新鲜 (0 ppt) 或微咸水 (16 ppt) 水中加入 GenX 长达 96 小时，以确定吸收和生物浓度。在暴露 96 小时后测定净化值，然后再暴露 96 小时后不暴露。生物浓度按血浆>肝脏>胴体>肌肉的递减顺序排列，肝脏的分布较高，其次是胴体和肌肉。发现肌肉的半衰期最长（1278 小时），其次是胴体（532 小时）、血浆（106 小时）和肝脏（152 小时）。吸收率和净化率受盐度的积极影响。由于所有组织中的生物浓度随着盐度的增加而增加，这可能会引起对海洋生物和人类暴露的担忧。