Both inhibitory and excitatory neurotransmitter receptors can influence maturation and survival of adult-born neurons in the dentate gyrus; nevertheless, how these two neurotransmitter systems affect integration of new neurons into the existing circuitry is still not fully characterized. Here, we demonstrate that glutamate receptors of the kainate receptor (KAR) subfamily are expressed in adult-born dentate granule cells (abDGCs) and that, through their interaction with GABAergic signaling mechanisms, they alter the functional properties of adult-born cells during a critical period of their development. Both the intrinsic properties and synaptic connectivity of young abDGCs were affected. Timed KAR loss in a cohort of young adult-born neurons in mice disrupted their performance in a spatial discrimination task but not in a hippocampal-dependent fear conditioning task. Together, these results demonstrate the importance of KARs in the proper functional development of young abDGCs.

抑制性和兴奋性神经递质受体均可影响齿状回中成年神经元的成熟和存活；然而，这两种神经递质系统如何影响新神经元整合到现有电路中仍不完全清楚。在这里，我们证明红藻氨酸受体 (KAR) 亚家族的谷氨酸受体在成年出生的齿状颗粒细胞 (abDGC) 中表达，并且通过它们与 GABA 信号传导机制的相互作用，它们改变了成年出生细胞的功能特性。其发展的关键时期。年轻 abDGC 的内在特性和突触连接都受到影响。一组年轻的成年小鼠神经元的定时 KAR 损失会扰乱它们在空间辨别任务中的表现，但不会扰乱海马依赖性恐惧调节任务的表现。总之，这些结果证明了 KAR 在年轻 abDGC 的正常功能发育中的重要性。