Nanotheranostics for fluorescence/magnetic resonance (FL/MR) dual-modal imaging guided photodynamic therapy (PDT) are highly desirable in precision and personalized medicine. In this study, a facile non-covalent electrostatic interaction induced self-assembly strategy is developed to effectively encapsulate gadolinium porphyrin (Gd-TCPP) into homogeneous supramolecular nanoparticles (referred to as Gd-PNPs). Gd-PNPs exhibit the following advantages: (1) excellent FL imaging property, high longitudinal relaxivity (16.157 mM⁻¹ s⁻¹), and good singlet oxygen (¹O₂) production property; (2) excellent long-term colloidal stability, dispersity and biocompatibility; and (3) enhanced in vivo FL/MR imaging guided tumor growth inhibition efficiency for CT 26 tumor-bearing mice. This study provides a new strategy to design and synthesize metalloporphyrin-based nanotheranostics for imaging-guided cancer therapy with enhanced theranostic properties.

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用于荧光/磁共振成像引导光动力治疗的基于钆-卟啉的聚合物纳米治疗学

用于荧光/磁共振 (FL/MR) 双模态成像引导光动力疗法 (PDT) 的纳米诊疗技术在精准和个性化医疗中非常受欢迎。在这项研究中，开发了一种简便的非共价静电相互作用诱导的自组装策略，以有效地将钆卟啉 (Gd-TCPP) 封装成均质的超分子纳米粒子（称为 Gd-PNPs）。Gd-PNPs具有以下优点：（1）优异的FL成像性能、高纵向弛豫率（16.157 mM ^-1 s ^-1）和良好的单线态氧（¹ O ₂）产生性能；(2)优异的长期胶体稳定性、分散性和生物相容性；(3)体内增强FL/MR 成像指导 CT 26 荷瘤小鼠的肿瘤生长抑制效率。这项研究为设计和合成基于金属卟啉的纳米治疗诊断提供了一种新策略，用于具有增强的治疗诊断特性的成像引导癌症治疗。