Repurposing an Antiviral Drug against SARS-CoV-2 Main Protease,Angewandte Chemie International Edition

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Repurposing an Antiviral Drug against SARS-CoV-2 Main Protease
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-09-21 , DOI: 10.1002/anie.202107481
Arighna Sarkar ₁ , Kalyaneswar Mandal ₁

Affiliation

This article highlights recent pioneering work by Günther et al. towards the discovery of potential repurposed antiviral compounds (peptidomimetic and non-peptidic) against the SARS-CoV-2 main protease (M^pro). The antiviral activity of the most potent drugs is discussed along with their binding mode to M^pro as observed through X-ray crystallographic screening.

中文翻译：

重新利用抗 SARS-CoV-2 主要蛋白酶的抗病毒药物

本文重点介绍了 Günther 等人最近的开创性工作。致力于发现针对 SARS-CoV-2 主要蛋白酶 (M ^pro ) 的潜在重新用途抗病毒化合物（肽模拟物和非肽）。讨论了最有效药物的抗病毒活性以及通过 X 射线晶体学筛选观察到的它们与 M ^{pro 的}结合模式。

更新日期：2021-10-19

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