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Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk
Movement Disorders ( IF 7.4 ) Pub Date : 2021-09-20 , DOI: 10.1002/mds.28787
Julie Lake 1 , Xylena Reed 1 , Rebekah G. Langston 1 , Mike A. Nalls 1, 2, 3 , Ziv Gan‐Or 4, 5, 6 , Mark R. Cookson 1 , Andrew B. Singleton 1, 2 , Cornelis Blauwendraat 1 , Hampton L. Leonard 1, 2, 3, 7 ,
Affiliation  

The leucine-rich repeat kinase 2 (LRRK2) gene harbors both rare highly damaging missense variants (eg, p.G2019S) and common noncoding variants (eg, rs76904798) with lower effect sizes that are associated with Parkinson's disease (PD) risk.

中文翻译:

LRRK2 的编码和非编码变异与帕金森病风险

富含亮氨酸的重复激酶 2 ( LRRK2 ) 基因包含罕见的高度破坏性错义变体(例如 p.G2019S)和常见的非编码变体(例如 rs76904798),其效应大小与帕金森病 (PD) 风险相关。
更新日期:2021-09-20
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