Reduced integrity of neural pathways from frontal to sensory cortices has been suggested as a potential neurobiological basis of attention-deficit hyperactivity disorder. Neurofeedback has been widely applied to enhance reduced neural pathways in attention-deficit hyperactivity disorder by repeated training on a daily temporal scale. Clinical and model-based studies have demonstrated that fluctuations in neural activity underpin sustained attention deficits in attention-deficit hyperactivity disorder. These aberrant neural fluctuations may be caused by the chaos-chaos intermittency state in frontal-sensory neural systems. Therefore, shifting the neural state from an aberrant chaos-chaos intermittency state to a normal stable state with an optimal external sensory stimulus, termed chaotic resonance, may be applied in neurofeedback for attention-deficit hyperactivity disorder. In this study, we applied a neurofeedback method based on chaotic resonance induced by "reduced region of orbit" feedback signals in the Baghdadi model for attention-deficit hyperactivity disorder. We evaluated the stabilizing effect of reduced region of orbit feedback and its robustness against noise from errors in estimation of neural activity. The effect of chaotic resonance successfully shifted the abnormal chaos-chaos intermittency of neural activity to the intended stable activity. Additionally, evaluation of the influence of noise due to measurement errors revealed that the efficiency of chaotic resonance induced by reduced region of orbit feedback signals was maintained over a range of certain noise strengths. In conclusion, applying chaotic resonance induced by reduced region of orbit feedback signals to neurofeedback methods may provide a promising treatment option for attention-deficit hyperactivity disorder.

中文翻译：

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使用混沌共振稳定 ADHD 异常神经活动的方法。

从额叶到感觉皮层的神经通路完整性降低被认为是注意力缺陷多动障碍的潜在神经生物学基础。神经反馈已被广泛应用于通过每天时间范围内的重复训练来增强注意力缺陷多动障碍中减少的神经通路。临床和基于模型的研究表明，神经活动的波动是注意力缺陷多动障碍持续注意力缺陷的基础。这些异常的神经波动可能是由额感觉神经系统中的混沌间歇状态引起的。因此，将神经状态从异常的混沌间歇状态转变为具有最佳外部感觉刺激的正常稳定状态，称为混沌共振，可用于注意力缺陷多动障碍的神经反馈。在这项研究中，我们在巴格达迪模型中应用了一种基于“轨道减少区域”反馈信号引起的混沌共振的神经反馈方法，用于注意力缺陷多动障碍。我们评估了轨道反馈减少区域的稳定效果及其对神经活动估计误差产生的噪声的鲁棒性。混沌共振的效果成功地将神经活动的异常混沌间歇性转变为预期的稳定活动。此外，对测量误差引起的噪声影响的评估表明，在一定的噪声强度范围内，轨道反馈信号减少区域引起的混沌共振效率保持不变。综上所述，