The SARS-CoV-2 pandemic has brought to light multiple considerations when approaching infectious diseases on the global level. These range from diagnostic platforms, to therapeutics, and prevention agents. In this article, we focus on the engineering platforms and considerations when applying serologic assays to multiple geographic locations, climates with varying endemic virus repertoires, and different laboratory and clinical resource settings. Serologic assays detect antibodies that react against viral proteins, suggesting prior infection and correlative of an increased likelihood of immunity to future infection. As these assays are focused on the human immune response to a pathogen, and humans are variable, there are a number of important engineering steps to optimize assay performance, from sample collection, to assay execution and data analysis. Moving forward, a global approach to infectious disease detection and prevention is necessary to prevent the spread of future viruses with pandemic potential. GRAPHIC ABSTRACT

中文翻译：

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全球传染病血清学检测的材料策略和注意事项。

SARS-CoV-2 大流行引发了全球应对传染病时的多种考虑因素。这些范围从诊断平台到治疗剂和预防剂。在本文中，我们重点讨论将血清学检测应用于多个地理位置、具有不同地方性病毒库的气候以及不同的实验室和临床资源设置时的工程平台和注意事项。血清学检测可检测到与病毒蛋白发生反应的抗体，表明先前存在感染，并与未来感染免疫力增加的可能性相关。由于这些测定的重点是人类对病原体的免疫反应，而人类是可变的，因此有许多重要的工程步骤来优化测定性能，从样品收集到测定执行和数据分析。展望未来，有必要采取全球性的传染病检测和预防方法，以防止未来具有大流行潜力的病毒的传播。图解摘要