The homeostasis model assessment of insulin resistance (HOMA-IR) is widely used in clinical practice to estimate insulin resistance. In particular, magnesium (Mg) is an extensively studied mineral that has been shown to function in the management of hyperglycemia and insulin resistance (IR) action. The pathophysiology of IR in non-obese patients has not been clearly demonstrated. From this point of view, we aimed to investigate the relationship between serum Mg level and IR in non-obese patients. We analyzed 957 patients who are not obese and estimated glomerular filtration rate (e-GFR) ≥ 60 mL/min/1.73 m2. Patients were divided into two groups, with and without IR. The results of the IR detected group (HOMA-IR ≥ 2.5, n = 544) and the IR undetected group (HOMA-IR < 2.5, n = 413) were compared. The median Mg value of the patients was 1.76 [0.21] mg/dL. A statistically significant difference was observed between the two groups regarding serum Mg levels (p = 0.043). A negative correlation was found between the HOMA-IR index and serum Mg levels among patients (r =  - 0.064, p = 0.049). Multivariable logistic regression analysis revealed that serum Mg level (p = 0.039, odds ratio [OR] = 0.770[95%CI: [0.917-0.989]) was independent risk factors for IR. HOMA-IR increases as the Mg level decreases in advanced ages without obesity, especially in men with low e-GFR.

中文翻译：

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土耳其非肥胖成人人群血清镁水平与胰岛素抵抗的关系。

胰岛素抵抗的稳态模型评估 (HOMA-IR) 在临床实践中广泛用于评估胰岛素抵抗。特别是，镁 (Mg) 是一种经过广泛研究的矿物质，已被证明在控制高血糖和胰岛素抵抗 (IR) 作用中发挥作用。非肥胖患者 IR 的病理生理学尚未得到明确证实。从这个角度来看，我们旨在研究非肥胖患者血清镁水平与 IR 之间的关系。我们分析了 957 名非肥胖患者，估计肾小球滤过率 (e-GFR) ≥ 60 mL/min/1.73 m2。患者分为两组，有和没有IR。比较IR检测组（HOMA-IR ≥ 2.5，n = 544）和IR未检测组（HOMA-IR < 2.5，n = 413）的结果。患者的中位 Mg 值为 1.76 [0. 21] 毫克/分升。两组血清镁水平存在统计学显着差异（p = 0.043）。患者的 HOMA-IR 指数与血清镁水平呈负相关（r = - 0.064，p = 0.049）。多变量逻辑回归分析显示血清镁水平（p = 0.039，优势比 [OR] = 0.770[95%CI：[0.917-0.989]）是 IR 的独立危险因素。在没有肥胖的高龄，特别是在 e-GFR 低的男性中，随着 Mg 水平的降低，HOMA-IR 会增加。优势比 [OR] = 0.770[95%CI: [0.917-0.989]) 是 IR 的独立危险因素。在没有肥胖的高龄，特别是在 e-GFR 低的男性中，随着 Mg 水平的降低，HOMA-IR 会增加。优势比 [OR] = 0.770[95%CI: [0.917-0.989]) 是 IR 的独立危险因素。在没有肥胖的高龄，特别是在 e-GFR 低的男性中，随着 Mg 水平的降低，HOMA-IR 会增加。