The skin represents the largest area for direct contact between microbes and host immunocytes and is a site for constant communication between the host and this diverse and essential microbial community. Coagulase-negative staphylococci are an abundant bacterial genus on the human skin and are regulated through various mechanisms that include the epidermal barrier environment and innate and adaptive immune systems within the epidermis and dermis. In turn, some species and strains of these bacteria produce beneficial products that augment host immunity by exerting specifically targeted antimicrobial, anti-inflammatory, or anti-neoplastic activity while also promoting broad innate and adaptive immune responses. The use of selected skin commensals as a therapeutic has shown promise in recent human clinical trials. This emerging concept of bacteriotherapy is defining mechanisms of action and validating the dependence on the microbiome for maintenance of immune homeostasis.

中文翻译：

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微生物组控制皮肤免疫功能的机制。

皮肤是微生物与宿主免疫细胞直接接触的最大区域，也是宿主与这个多样化和重要的微生物群落之间不断交流的场所。凝固酶阴性葡萄球菌是人体皮肤上丰富的细菌属，并通过各种机制进行调节，包括表皮屏障环境以及表皮和真皮内的先天和适应性免疫系统。反过来，这些细菌的某些物种和菌株会产生有益产物，通过发挥特异性靶向抗菌、抗炎或抗肿瘤活性来增强宿主免疫力，同时促进广泛的先天性和适应性免疫反应。在最近的人体临床试验中，使用选定的皮肤共生体作为治疗剂已显示出前景。