So far, various etiologies have been stated for Intra-uterine growth restriction (IUGR) with a wide variety of pathways involved in their pathogenesis. Among these pathways, impaired angiogenesis, inflammation, and oxidative stress are among the most important ones. Curcumin has raised notable attention due to its anti-inflammatory and antioxidant activity in different studies and clinical trials. The present study aimed to investigate the possible potentials of Curcumin for pregnancies complicated by IUGR through different physiological mechanisms. A narrative review study was conducted (Iran; 2020). The implemented Mesh-based keywords were “Curcumin” OR “Turmeric” AND “Therapeutic effect” AND “Side effect” OR “Adverse effect” OR “Teratogenic effect” OR “Teratogenicity” AND “Pregnancy” AND “Intra-uterine growth restriction” OR “Intra-uterine growth retardation” AND “Inflammation” AND “Oxidative stress” AND “Angiogenesis”. Cochrane Library, PubMed, Up to date, Scopus, and Google Scholar databases were used as academic search engines. Reviewing the included studies showed the dual effects of curcumin on angiogenesis depend on the type of angiogenesis: physiological or pathological. Interestingly, the present study evaluated the current knowledge on the effects of curcumin on IUGR demonstrating acceptable potentials. Also, we tried to gather studies that had evaluated the safety of curcumin during pregnancy. Gathering all the data, it seems curcumin could be an acceptable candidate for future animal and human studies on IUGR.

中文翻译：

---

姜黄素对子宫内生长受限并发妊娠的潜在潜力：炎症、血管生成和氧化应激的作用


迄今为止，已经阐明了子宫内生长受限（IUGR）的多种病因，其发病机制涉及多种途径。在这些途径中，血管生成受损、炎症和氧化应激是最重要的途径。姜黄素因其抗炎和抗氧化活性在不同的研究和临床试验中引起了人们的广泛关注。本研究旨在探讨姜黄素通过不同的生理机制治疗 IUGR 妊娠的可能潜力。进行了一项叙述性回顾研究（伊朗；2020）。实施的基于网格的关键词是“姜黄素”或“姜黄”和“治疗效果”和“副作用”或“副作用”或“致畸作用”或“致畸性”和“妊娠”和“子宫内生长受限”或“子宫内生长迟缓”和“炎症”和“氧化应激”和“血管生成”。 Cochrane Library、PubMed、Up to date、Scopus 和 Google Scholar 数据库被用作学术搜索引擎。回顾纳入的研究表明，姜黄素对血管生成的双重影响取决于血管生成的类型：生理性或病理性。有趣的是，本研究评估了姜黄素对 IUGR 影响的现有知识，证明了姜黄素具有可接受的潜力。此外，我们还尝试收集评估姜黄素在怀孕期间安全性的研究。收集所有数据后，姜黄素似乎可以成为未来 IUGR 动物和人类研究的可接受候选者。