Dynamic lipid aptamers: non-polymeric chemical path to early life,Chemical Society Reviews

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Dynamic lipid aptamers: non-polymeric chemical path to early life
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2021-09-20 , DOI: 10.1039/d1cs00633a
Amit Kahana ₁ , Svetlana Maslov ₁ , Doron Lancet ₁

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A widespread dogma asserts that life could not have emerged without biopolymers – RNA and proteins. However, the widely acknowledged implausibility of a spontaneous appearance and proliferation of these complex molecules in primordial messy chemistry casts doubt on this scenario. A proposed alternative is “Lipid-First”, based on the evidence that lipid assemblies may spontaneously emerge in heterogeneous environments, and are shown to undergo growth and fission, and to portray autocatalytic self-copying. What seems undecided is whether lipid assemblies have protein-like capacities for stereospecific interactions, a sine qua non of life processes. This Viewpoint aims to alleviate such doubts, pointing to growing experimental evidence that lipid aggregates possess dynamic surface configurations capable of stereospecific molecular recognition. Such findings help support a possible key role of lipids in seeding life's origin.

中文翻译：

动态脂质适体：早期生命的非聚合化学途径

一个普遍的教条断言，如果没有生物聚合物——RNA 和蛋白质，生命就不可能出现。然而，这些复杂分子在原始凌乱化学中自发出现和增殖的广泛公认的不可信性使人们对这种情况产生怀疑。一个提议的替代方案是“脂质优先”，基于脂质组装可能在异质环境中自发出现的证据，并显示出经历生长和裂变，并描绘自催化自我复制。似乎尚未确定的是脂质组装体是否具有类似蛋白质的立体特异性相互作用能力，这是一个必要的条件生命过程。该观点旨在减轻此类疑虑，指出越来越多的实验证据表明脂质聚集体具有能够立体特异性分子识别的动态表面构型。这些发现有助于支持脂质在种子生命起源中可能发挥的关键作用。

更新日期：2021-09-20

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