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Development of an enolate alkynylation approach towards the synthesis of the taiwanschirin natural products
Chemical Science ( IF 7.6 ) Pub Date : 2021-09-20 , DOI: 10.1039/d1sc04247e Maxwell B Haughey 1 , Kirsten E Christensen 1 , Darren L Poole 2 , Timothy J Donohoe 1
Chemical Science ( IF 7.6 ) Pub Date : 2021-09-20 , DOI: 10.1039/d1sc04247e Maxwell B Haughey 1 , Kirsten E Christensen 1 , Darren L Poole 2 , Timothy J Donohoe 1
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Through the use of model studies, an approach was conceived towards the synthesis of the taiwanschirin family of natural products. These are structurally complex compounds which represent highly challenging and biologically active targets for total synthesis. This work describes a successful synthesis of the complex taiwanschirin fused [8,6,5] core through a novel alkynylation reaction coupled with an intramolecular Heck reaction used to construct the 8-membered ring.
更新日期：2021-09-20
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