Objective

To report on the psychological, personality, and behavioral profiles of individuals with persistent Mal de Débarquement Syndrome (MdDS).

Materials and methods

Individuals with MdDS who participated in neuromodulation clinical trials between May 2013 and June 2019 completed a series of standardized psychological questionnaires and underwent the Structural Clinical Interview for DSM-IV-TR (SCID) for specific psychiatric diagnoses. All data reported are from baseline assessments prior to any study interventions. Scores were compared to population norms for adult women.

Results

Complete datasets were available for 55 women. Mean age of onset of MdDS was 49.0 ± 11.9 years (range 22–69 years) and median duration of illness of 22 months (6 months–20 years). SCID results were as follows: healthy (48.1%), any lifetime Major Depressive Disorder (35.2%, 7.4% current); any lifetime history of anxiety disorder (11.1%); any lifetime substance use disorders (18.5%, 0% current). Compared to population norms, the MdDS group scored significantly higher on the Patient Health Questionnaire-9 depression scale and the Generalized Anxiety Disorder 7 (GAD-7) anxiety scale, but only the GAD-7 correlated with symptom severity. The NEO-Five Factor Inventory for personality, Positive and Negative Affect Schedule, Behavioral Inhibition System/Behavioral Activation System Scale, and the Empathy Quotient metrics did not correlate with duration of illness. Disability assessed by the 12-item World Health Organization Disability Assessment Schedule 2.0 was 25.7 ± 6.7, comparable to reports for concussion. Disability correlated with severity of depression, anxiety, neuroticism, and affect but not to severity of MdDS.

Conclusions

Psychological profiles of MdDS relate to disability but not to duration of illness.

中文翻译：

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Mal de Débarquement 综合征患者的心理评估

客观的

报告持续性 Mal de Dé barquement综合征 (MdDS) 患者的心理、人格和行为特征。

材料和方法

在 2013 年 5 月至 2019 年 6 月期间参加神经调节临床试验的 MdDS 患者完成了一系列标准化心理问卷，并接受了DSM-IV-TR (SCID) 的结构临床访谈，以进行特定的精神病诊断。报告的所有数据均来自任何研究干预之前的基线评估。将分数与成年女性的人口标准进行比较。

结果

完整的数据集可用于 55 名女性。MdDS 的平均发病年龄为 49.0 ± 11.9 岁（范围 22-69 岁），中位病程为 22 个月（6 个月-20 岁）。SCID 结果如下：健康（48.1%），任何一生的重度抑郁症（35.2%，当前 7.4%）；任何焦虑症的终生病史（11.1%）；任何终生物质使用障碍（18.5%，当前为 0%）。与人群标准相比，MdDS 组在患者健康问卷 9 抑郁量表和广泛性焦虑症 7 (GAD-7) 焦虑量表上得分显着更高，但只有 GAD-7 与症状严重程度相关。NEO-人格五因素量表，正面和负面影响时间表，行为抑制系统/行为激活系统量表，移情商指标与疾病持续时间无关。由 12 项世界卫生组织残疾评估表 2.0 评估的残疾为 25.7 ± 6.7，与脑震荡报告相当。残疾与抑郁、焦虑、神经质和情感的严重程度相关，但与 MdDS 的严重程度无关。

结论

MdDS 的心理特征与残疾有关，但与病程无关。