Introduction. Sex hormones play an important role in the development and maintenance of bone and muscle mass. However, studies regarding serum testosterone levels, osteoporosis, and sarcopenia in men are relatively sparse and have led to contradictory conclusions. Therefore, this study aimed to investigate the association between serum testosterone levels and body composition, including bone mineral density (BMD), appendicular lean mass index (ALMI), and appendicular fat mass index (AFMI), among men 20–59 years of age through a cross-sectional analysis of the National Health and Nutrition Examination Survey. Materials and Methods. Our analysis was based on the data for 3,875 men, 20–59 years of age. Weighted multiple regression analyses were used to estimate the independent association between serum testosterone levels and body composition. Weighted generalized additive models and smooth curve fittings were used to characterize the nonlinear associations between them. Results. The association between the serum testosterone level and lumbar BMD was positive in each multivariable linear regression model. In the model adjusted for age and race, the serum testosterone level was negatively associated with ALMI. However, in the models adjusted for body mass index, this association became positive. In addition, the association between the serum testosterone level and AFMI was negative in each multivariable linear regression model. Conclusion. Our study demonstrated a positive association of serum testosterone level with lumbar BMD and ALMI, and a negative association with AFMI, among men 20–59 years of age, suggesting that increasing testosterone levels may be beneficial to skeletal health in young and middle-aged men with low testosterone levels.

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20-59 岁男性血清睾酮水平与身体成分之间的关​​联

简介。性激素在骨骼和肌肉质量的发育和维持中起着重要作用。然而，关于男性血清睾酮水平、骨质疏松症和肌肉减少症的研究相对较少，并导致了相互矛盾的结论。因此，本研究旨在调查 20-59 岁男性血清睾酮水平与身体成分之间的关​​系，包括骨矿物质密度 (BMD)、四肢瘦体重指数 (ALMI) 和四肢脂肪质量指数 (AFMI)通过对全国健康和营养检查调查的横断面分析。材料和方法. 我们的分析基于 3,875 名 20-59 岁男性的数据。加权多元回归分析用于估计血清睾酮水平与身体成分之间的独立关联。加权广义加性模型和平滑曲线拟合用于表征它们之间的非线性关联。结果。在每个多变量线性回归模型中，血清睾酮水平与腰椎 BMD 之间的关联均为正相关。在根据年龄和种族调整的模型中，血清睾酮水平与 ALMI 呈负相关。然而，在根据体重指数调整的模型中，这种关联变成了积极的。此外，在每个多变量线性回归模型中，血清睾酮水平与 AFMI 之间的关联均为负相关。结论。我们的研究表明，在 20-59 岁的男性中，血清睾酮水平与腰椎 BMD 和 ALMI 呈正相关，与 AFMI 呈负相关，这表明增加睾酮水平可能有益于中青年男性的骨骼健康睾酮水平低。