Plant natural products are a plethora of diverse and complex molecules produced by the plant secondary metabolism. Among these, many can reserve beneficial or curative properties when employed to treat human diseases. Even in cancer, they can be successfully used and indeed numerous phytochemicals exert antineoplastic activity. The most common molecules derived from plants and used in the fight against cancer are polyphenols, i.e., quercetin, genistein, resveratrol, curcumin, etc. Despite valuable data especially in preclinical models on such compounds, few of them are currently used in the medical practice. Also, in adrenocortical tumors (ACT), phytochemicals are scarcely or not at all used. This work summarizes the available research on phytochemicals used against ACT and adrenocortical cancer, a very rare disease with poor prognosis and high metastatic potential, and wants to contribute to stimulate preclinical and clinical research to find new therapeutic strategies among the overabundance of biomolecules produced by the plant kingdom.

中文翻译：

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治疗肾上腺皮质肿瘤的植物天然化合物

植物天然产物是由植物次生代谢产生的大量多样化和复杂的分子。其中，当用于治疗人类疾病时，许多可以保留有益或治疗特性。即使在癌症中，它们也可以成功使用，并且确实许多植物化学物质发挥抗肿瘤活性。来自植物并用于抗癌的最常见的分子是多酚，即槲皮素、染料木素、白藜芦醇、姜黄素等。 尽管这些化合物的临床前模型中的数据很有价值，但目前很少用于医疗实践. 此外，在肾上腺皮质肿瘤 (ACT) 中，几乎不使用或根本不使用植物化学物质。这项工作总结了用于对抗 ACT 和肾上腺皮质癌的植物化学物质的现有研究，