Sjogren’s syndrome (SS) is a heterogenous disease with various phenotypes. We aimed to provide a relevant subclassification based on symptom-based clustering for patients with primary (p) SS. Data from patients in a prospective pSS cohort in Korea were analysed. Latent class analysis (LCA) was performed using patient reported outcomes, including pain, fatigue, dryness, and anxiety/depression. Clinical and laboratory differences between the classes were analysed. Latent transition analysis (LTA) was applied to the longitudinal data (annually for up to 5 years) to assess temporal stability of the classifications. LCA identified three classes among 341 patients with pSS (i.e., ‘high symptom burden’, ‘dryness dominant’, ‘low symptom burden’). Each group had distinct laboratory and clinical phenotypes. LTA revealed that class membership remained stable over time. Baseline class predicted future salivary gland function and damage accrual represented by a Sjogren’s syndrome disease damage index. Symptom-based clustering of heterogenous patients with primary Sjogren’s syndrome provided a relevant classification supported by temporal stability over time and distinct phenotypes between the classes. This clustering strategy may provide more homogenous groups of pSS patients for novel treatment development and predict future phenotypic evolvement.

中文翻译：

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原发性干燥综合征患者基于症状聚类的纵向分析：一项具有 5 年随访期的前瞻性队列研究

干燥综合征 (SS) 是一种具有多种表型的异质性疾病。我们旨在为原发性 (p) SS 患者提供基于症状聚类的相关子分类。分析了来自韩国前瞻性 pSS 队列患者的数据。使用患者报告的结果进行潜在类别分析 (LCA)，包括疼痛、疲劳、干燥和焦虑/抑郁。分析了班级之间的临床和实验室差异。对纵向数据（每年最多 5 年）应用潜在转变分析 (LTA) 以评估分类的时间稳定性。LCA 在 341 名 pSS 患者中确定了三类（即“高症状负担”、“干燥显性”、“低症状负担”）。每组具有不同的实验室和临床表型。LTA 透露，随着时间的推移，班级成员保持稳定。基线等级预测了未来的唾液腺功能和损伤累积，由干燥综合征疾病损伤指数表示。原发性干燥综合征异质性患者基于症状的聚类提供了相关分类，该分类由随时间推移的时间稳定性和类别之间的不同表型提供支持。这种聚类策略可以为新的治疗开发提供更同质的 pSS 患者组，并预测未来的表型演变。基于症状的原发性干燥综合征异质患者聚类提供了相关分类，该分类由随时间推移的时间稳定性和类别之间的不同表型提供支持。这种聚类策略可以为新的治疗开发提供更同质的 pSS 患者组，并预测未来的表型演变。基于症状的原发性干燥综合征异质患者聚类提供了相关分类，该分类由随时间推移的时间稳定性和类别之间的不同表型提供支持。这种聚类策略可以为新的治疗开发提供更同质的 pSS 患者组，并预测未来的表型演变。