Objective

In patients with brain lesion, awareness of cognitive deficits is an important aspect of disease awareness. Glioblastoma (GBM) and anaplastic astrocytoma (AA) can cause cognitive deficits, but, to date, awareness of these deficits has not been documented. This study aimed to test cognitive awareness in these patients after the end of treatment.

Methods

Fifty patients with GBM or AA were assessed using the Multiple Ability Self-Report Questionnaire (MASQ), State-Trait Anxiety Inventory (STAI), Self Rating Depression Scale (SRDS), and memory, attention, mental speed, abstract reasoning, and flexibility neuropsychological tests. Cognitive awareness was calculated as the concordance between the composite score of neuropsychological performance (PEC) and the total MASQ score. The controls were 48 healthy subjects. Analysis of variance and regression analysis compared subject groups and explored variables predicting perceived abilities.

Results

Patients with GBM or AA showed similar attention, memory, and executive deficits compared with controls. Cognitive awareness was fair/full in 64% of patients. In the entire patients group, the worst MASQ scores were associated with neuropsychological deficits, anxiety, depression, and glioma location in the right hemisphere . In patients with fair/full awareness, MASQ scores were related to affective status and neuropsychological performance, whereas, in those with scarce/no awareness, they were related only to affective status.

Conclusions

After treatment, many patients with GBM or AA are aware of their cognitive deficits. Anxiety, depression, and right hemisphere tumour exacerbate the perceived difficulties. This neurocognitive approach expands the behavioural phenotypes of high-grade gliomas and may have therapeutic implications over the course of the disease.

中文翻译：

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高级别胶质瘤治疗后的认知意识

客观的

在脑损伤患者中，对认知缺陷的认识是疾病认识的一个重要方面。胶质母细胞瘤 (GBM) 和间变性星形细胞瘤 (AA) 可导致认知缺陷，但迄今为止，尚未记录对这些缺陷的认识。本研究旨在测试这些患者在治疗结束后的认知意识。

方法

使用多能力自我报告问卷 (MASQ)、状态特质焦虑量表 (STAI)、自我评定抑郁量表 (SRDS) 以及记忆力、注意力、思维速度、抽象推理和灵活性对 50 名 GBM 或 AA 患者进行了评估神经心理学测试。认知意识被计算为神经心理表现（PEC）综合得分与 MASQ 总得分之间的一致性。对照组为 48 名健康受试者。方差分析和回归分析比较了受试者组并探索了预测感知能力的变量。

结果

与对照组相比，GBM 或 AA 患者表现出相似的注意力、记忆力和执行力缺陷。64% 的患者的认知意识是公平/充分的。在整个患者组中，最差的 MASQ 评分与右半球的神经心理缺陷、焦虑、抑郁和胶质瘤位置有关。在意识一般/完全意识的患者中，MASQ 评分与情感状态和神经心理表现有关，而在意识稀少/无意识的患者中，它们仅与情感状态有关。

结论

治疗后，许多 GBM 或 AA 患者意识到他们的认知缺陷。焦虑、抑郁和右半球肿瘤加剧了感知困难。这种神经认知方法扩展了高级别胶质瘤的行为表型，并可能在疾病过程中产生治疗意义。