Background

Among patients in the United States with psoriasis (PsO), limited data exist on the incidence and prevalence of psoriatic arthritis (PsA) based on disease severity.

Objective

To assess the incidence, prevalence, and predictors of PsA among patients with PsO stratified by PsO severity using treatment type.

Methods

Incidence of PsA per 100 PsO patient-years (PY) and prevalence were assessed using the Optum electronic health records database. Incidence was assessed from PsO diagnosis and 1 year after PsO diagnosis overall and stratified by mutually exclusive treatment classes as a severity surrogate.

Results

The overall incidence of PsA was 2.9 (95% CI, 2.9-3.0) events per 100 PY. The incidence (95% CI) by severity surrogate was 2.1 (2.1-2.1), 9.9 (9.5-10.4), and 17.6 (16.9-18.3) events per 100 PY for patients with mild, moderate, and severe PsO as determined by receiving nonsystemics, nonbiologic systemic therapy, and biologics, respectively. When excluding patients diagnosed with PsA 1 year after PsO diagnosis, overall incidence was lower (1.7 [95% CI, 1.6-1.7] events per 100 PY), with similar trends for treatment-severity surrogates.

Limitations

Results may not be generalizable to a wider population.

Conclusion

The risk of developing PsA increased with disease severity and was highest in patients with the most severe PsO.

中文翻译：

---

按银屑病严重程度分层的银屑病患者银屑病关节炎的发病率和患病率：美国电子健康记录数据库的回顾性分析

背景

在美国银屑病 (PsO) 患者中，基于疾病严重程度的银屑病关节炎 (PsA) 发病率和患病率的数据有限。

客观的

评估使用治疗类型按 PsO 严重程度分层的 PsO 患者中 PsA 的发病率、患病率和预测因子。

方法

使用 Optum 电子健康记录数据库评估每 100 PsO 患者年 (PY) 的 PsA 发病率和患病率。从 PsO 诊断开始和 PsO 诊断后 1 年总体评估发病率，并通过相互排斥的治疗类别作为严重程度的替代指标进行分层。

结果

PsA 的总发生率为每 100 PY 2.9（95% CI，2.9-3.0）事件。对于轻度、中度和重度 PsO 患者，按严重程度替代的发生率 (95% CI) 为每 100 PY 2.1 (2.1-2.1)、9.9 (9.5-10.4) 和 17.6 (16.9-18.3) 事件，通过接受分别是非全身治疗、非生物全身治疗和生物治疗。当排除 PsO 诊断后 1 年诊断为 PsA 的患者时，总体发生率较低（每 100 PY 1.7 [95% CI，1.6-1.7] 事件），治疗严重性替代指标的趋势相似。

限制

结果可能无法推广到更广泛的人群。

结论

患 PsA 的风险随着疾病的严重程度而增加，并且在 PsO 最严重的患者中风险最高。