Objectives

Sickle cell disease is a common haemoglobinopathy that significantly increases the risk of ischemic stroke. Because the risk factors for ischemic stroke onset and mortality in non-sickle cell disease patients have been largely elucidated, this paper aims to analyze risk factors for ischemic stroke mortality in sickle cell disease patients, which remain largely unknown.

Materials/Methods

The National Inpatient Sample database (2016–2017) was used to develop a multivariable regression model for risk quantification of known ischemic stroke risk factors for in-hospital mortality in ischemic stroke patients with and without sickle cell disease.

Results

Classical risk factors for ischemic stroke onset, including ischemic heart disease, carotid artery disease, lipidemias, hypertension, obesity, tobacco use, atrial fibrillation, personal or family history of stroke, congenital heart defects, congestive heart failure, cardiac valve disorder, peripheral vascular disease, and diabetes mellitus are associated with in-hospital mortality in non-sickle cell patients (p < 0.05). However, no significant association was found between these stroke risk factors and in-hospital mortality in sickle cell disease patients presenting with ischemic stroke (p > 0.05).

Conclusions

While the classical risk factors for stroke onset are associated with in-hospital mortality in non-sickle cell stroke patients, they are not associated with in-hospital mortality in sickle cell stroke patients.

中文翻译：

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缺血性卒中的经典危险因素与镰状细胞病患者卒中后死亡率无关

目标

镰状细胞病是一种常见的血红蛋白病，会显着增加缺血性中风的风险。由于非镰状细胞病患者缺血性卒中发病和死亡的危险因素已基本阐明，本文旨在分析镰状细胞病患者缺血性卒中死亡的危险因素，这些因素在很大程度上仍是未知的。

材料/方法

国家住院患者样本数据库（2016-2017）用于开发多变量回归模型，用于对患有和不患有镰状细胞病的缺血性卒中患者院内死亡率的已知缺血性卒中风险因素进行风险量化。

结果

缺血性中风发作的经典危险因素，包括缺血性心脏病、颈动脉疾病、血脂、高血压、肥胖、吸烟、心房颤动、中风个人或家族史、先天性心脏缺陷、充血性心力衰竭、心脏瓣膜疾病、外周血管疾病和糖尿病与非镰状细胞患者的住院死亡率相关（p  < 0.05）。然而，这些卒中危险因素与镰状细胞病缺血性卒中患者的住院死亡率之间没有显着相关性（p  > 0.05）。

结论

虽然中风发作的经典危险因素与非镰状细胞中风患者的院内死亡率相关，但它们与镰状细胞中风患者的院内死亡率无关。