Orodispersible films (ODFs) are ultra-thin, stamp-sized, elegant, portable and patient-centric pharmaceutical dosage forms that do not need water to be ingested. They are particularly useful for paediatric and geriatric patient populations with special needs such as dysphagia, Parkinson’s disease, and oral cancer. Accordingly, they hold tremendous potential in gaining patient compliance, convenience and pharmacotherapy. In the present review, conception and evolution of ODFs as a product and its technology are discussed. The review continues by providing overview about the potential of ODFs as carriers for delivering drugs, herbal extracts, probiotics and vaccines. Besides, strategies employed in drug cargo loading, taste masking of bitter drugs and enhancing drug stability are discussed. Finally, the review concludes by providing a brief overview about quality by design (QbD) principles in development of ODFs.

口腔分散薄膜 (ODF) 是超薄、印章大小、优雅、便携且以患者为中心的药物剂型，不需要摄入水。它们特别适用于有吞咽困难、帕金森病和口腔癌等特殊需求的儿科和老年患者群体。因此，它们在获得患者依从性、便利性和药物治疗方面具有巨大潜力。在本综述中，讨论了 ODF 作为产品及其技术的概念和演变。审查继续概述 ODF 作为药物、草药提取物、益生菌和疫苗载体的潜力。此外，还讨论了药物装载、苦味药物掩味和提高药物稳定性的策略。最后，