Background

CMV infection prevalence in kidney transplant recipients (KTR) is reported to be high in the literature, reaching rates of over 80%.

Objectives

The primary endpoints were the evaluation of the prevalence, the risks factors, and the effects of CMV infection on graft function and survival, as well as patient survival at three years after kidney transplantation.

Material and methods

We retrospectively reviewed the medical records of 288 kidney transplant patients operated in three Lebanese transplant centers between 1998 and 2017 with three years of follow-up. The patients were divided into two groups: those free of any CMV infection (271 patients (94%); Group I) and those who suffered from CMV infection (17 patients (6%); Group II).

Results

Baseline demographics of the two groups were similar, including recipient and donor gender and age, cause of renal disease, recipient body mass index, pre-transplant fasting blood sugar and dialysis duration, HLA matching between donor and recipient, degree of sensitization in the recipient, type of CMV prophylaxis, maintenance immunosuppression and immunological characteristics. The prevalence of CMV infection is 5.9% among KTR. There were significant differences between the two groups concerning the type of induction therapy and the duration of anti-CMV prophylaxis. The rate of infected patients and infectious episodes were significantly higher in Group II. At 3-years, graft function and survival, patient survival, and the rate of new-onset diabetes were similar between the two groups.

Conclusion

The present study is the first to explore the incidence and risk factors of CMV in kidney transplant patients in Lebanon. Comprehensive nationwide studies are therefore necessary to determine the epidemiology and risk factors of CMV infection after kidney transplantation in Lebanon.

中文翻译：

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肾移植患者的巨细胞病毒感染：患病率、危险因素和对结果的影响——当地多中心经验

背景

据报道，肾移植受者 (KTR) 的 CMV 感染率很高，达到 80% 以上。

目标

主要终点是评估 CMV 感染的患病率、风险因素和对移植物功能和存活率的影响，以及肾移植后三年的患者存活率。

材料与方法

我们回顾性审查了 1998 年至 2017 年间在三个黎巴嫩移植中心手术的 288 名肾移植患者的医疗记录，并进行了三年的随访。将患者分为两组：无CMV感染者（271例（94%）；I组）和CMV感染者（17例（6%）；II组）。

结果

两组的基线人口统计数据相似，包括受者和供者的性别和年龄、肾脏疾病的原因、受者体重指数、移植前空腹血糖和透析时间、供者和受者之间的 HLA 匹配、受者的致敏程度，CMV预防类型，维持免疫抑制和免疫学特征。KTR中CMV感染的患病率为5.9%。两组在诱导治疗类型和抗 CMV 预防持续时间方面存在显着差异。第二组感染患者和感染事件的发生率明显较高。在 3 年时，两组的移植物功能和存活率、患者存活率以及新发糖尿病的发生率相似。

结论

本研究首次探讨黎巴嫩肾移植患者 CMV 的发病率和危险因素。因此，有必要进行全面的全国性研究，以确定黎巴嫩肾移植后 CMV 感染的流行病学和危险因素。