A Ni-catalyzed reductive cross-coupling between α-C-tosyl peptides and Csp² triflates/halides has been developed. This protocol enables the formation of various unnatural di- and tripeptides containing vinyl and aryl side chains, and it expands the applications of Ni-catalyzed reductive cross-coupling in late-stage diversification of peptides.

中文翻译：

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通过 α-C-甲苯磺酰肽与 Csp2 三氟甲磺酸盐/卤化物的镍催化还原偶联使肽的烯基化和芳基化

已经开发了α-C-甲苯磺酰肽和 Csp ²三氟甲磺酸盐/卤化物之间的 Ni 催化还原交叉偶联。该协议能够形成各种含有乙烯基和芳基侧链的非天然二肽和三肽，并扩展了镍催化还原交叉偶联在肽后期多样化中的应用。