Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, allowing cancer cells to escape apoptosis triggered by these receptors while promoting in parallel major aspects of tumorigenesis such as proliferation, angiogenesis, invasiveness, and chemoresistance. This involvement in multiple cancer hallmarks has raised interest in dependence receptors as targets for cancer therapy. Although additional studies remain necessary to fully understand the complexity of signaling pathways activated by these receptors and to target them efficiently, it is now clear that dependence receptors represent very exciting targets for future cancer treatment. This manuscript reviews current knowledge on the contribution of dependence receptors to cancer and highlights the potential for therapies that activate pro-apoptotic functions of these proteins.

中文翻译：

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依赖性受体：癌症治疗的新靶点

众所周知，依赖性受体在激活时可促进存活和积极信号传导，例如增殖、迁移和分化，但在与其配体未结合时会主动触发细胞凋亡。它们的异常调节被证明是肿瘤发生的一个重要特征，使癌细胞能够逃避这些受体引发的细胞凋亡，同时促进肿瘤发生的主要方面，如增殖、血管生成、侵袭性和化疗耐药性。这种涉及多种癌症标志的现象引起了人们对依赖受体作为癌症治疗靶点的兴趣。尽管还需要进行更多的研究来充分了解这些受体激活的信号通路的复杂性并有效地靶向它们，但现在很明显，依赖性受体代表了未来癌症治疗的非常令人兴奋的目标。该手稿回顾了有关依赖性受体对癌症的贡献的最新知识，并强调了激活这些蛋白质促凋亡功能的疗法的潜力。