Streptococcus pneumoniae is an important pathogen that causes otitis media, pneumonia, meningitis and bacteremia. As an important virulence factors of S. pneumoniae, pneumolysin (PLY) can penetrate cell membranes and lead to cell lysis and inflammation, which is one of the main causes of infection and damage of S. pneumoniae. Therefore, using pneumolysin as a target to study its inhibitors can provide a new treatment strategy for pneumococcal disease. This study analyzed the inhibitory effect of the natural compound hederagenin on PLY in vitro. The results show that hederagenin has great potential as a new strategy for the treatment of pneumococcal diseases.

肺炎链球菌是引起中耳炎、肺炎、脑膜炎和菌血症的重要病原体。作为肺炎链球菌的重要毒力因子，肺炎链球菌溶血素(pneumolysin，PLY)可穿透细胞膜，导致细胞溶解和炎症，是肺炎链球菌感染和破坏的主要原因之一。因此，以肺炎球菌溶血素为靶点研究其抑制剂可为肺炎球菌病提供新的治疗策略。本研究分析了天然复方常春藤素在体外对PLY的抑制作用。结果表明，常春藤素作为治疗肺炎球菌疾病的新策略具有巨大潜力。