Basolateral amygdala stimulation plus water maze training restore dentate gyrus LTP and improve spatial learning and memory,Behavioural Brain Research

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Basolateral amygdala stimulation plus water maze training restore dentate gyrus LTP and improve spatial learning and memory
Behavioural Brain Research ( IF 2.6 ) Pub Date : 2021-09-20 , DOI: 10.1016/j.bbr.2021.113589
Daymara Mercerón-Martínez ₁ , William Almaguer-Melian ₁ , Jorge A Bergado ₂

Affiliation

Synaptic plasticity is a key mechanism of neural plasticity involved in learning and memory. A reduced or impaired synaptic plasticity could lead to a deficient learning and memory. On the other hand, besides reducing hipocampal dependent learning and memory, fimbria-fornix lesion affects LTP. However, we have consistently shown that stimulation of the basolateral amygdala (BLA) 15 min after water maze training is able to improve spatial learning and memory in fimbria fornix lesioned rats while also inducing changes in the expression of plasticity-related genes expression in memory associated brain regions like the hippocampus and prefrontal cortex. In this study we test that hypothesis: whether BLA stimulation 15 min after water maze training can improve LTP in the hippocampus of fimbria-fornix lesioned rats. To address this question, we trained fimbria-fornix lesioned rats in water maze for four consecutive days, and the BLA was bilaterally stimulated 15 min after each training session.Our data show that trained fimbria-fornix lesioned rats develop a partially improved LTP in dentated gyrus compared with the non-trained fimbria-fornix lesioned rats. In contrast, dentated gyrus LTP in trained and BLA stimulated fimbria-fornix lesioned rats improved significantly compared to the trained fimbria-fornix lesioned rats, but was not different from that shown by healthy animals. BLA stimulation in non-trained FF lesioned rats did not improve LTP; instead produces a transient synaptic depression. Restoration of the ability to develop LTP by the combination of training and BLA stimulation would be one of the mechanisms involved in ameliorating memory deficits in lesioned animals.

中文翻译：

基底外侧杏仁核刺激加水迷宫训练恢复齿状回LTP并改善空间学习和记忆

突触可塑性是参与学习和记忆的神经可塑性的关键机制。突触可塑性降低或受损可能导致学习和记忆缺陷。另一方面，除了减少海马依赖性学习和记忆外，穹窿伞损伤还会影响 LTP。然而，我们一致表明，水迷宫训练后 15 分钟刺激基底外侧杏仁核 (BLA) 能够改善穹窿伞损伤大鼠的空间学习和记忆，同时还能诱导记忆相关可塑性相关基因表达的变化。大脑区域，如海马体和前额皮质。在这项研究中，我们测试了这个假设：水迷宫训练后 15 分钟的 BLA 刺激是否可以改善穹窿伞损伤大鼠海马的 LTP。为了解决这个问题，我们在水迷宫中连续训练了穹窿伞损伤的大鼠四天，每次训练后 15 分钟刺激双侧 BLA。我们的数据显示，经过训练的穹窿伞损伤大鼠的 LTP 得到部分改善。与未经训练的穹窿伞损伤大鼠相比。相反，与训练过的穹窿伞损伤大鼠相比，经过训练和BLA刺激的穹窿伞损伤大鼠的齿状回LTP显着改善，但与健康动物没有不同。对未经训练的 FF 损伤大鼠进行 BLA 刺激并不能改善 LTP；相反会产生短暂的突触抑制。通过训练和 BLA 刺激相结合来恢复 LTP 发展的能力将是改善受损动物记忆缺陷的机制之一。

更新日期：2021-09-20

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