The maternal diet can impact offspring development, yet the mechanisms responsible for this remain largely unknown. New research shows that oocyte metabolites, specifically NAD+ and the methyl donor S-adenosylmethionine, can mediate the impact of maternal nutrient stress on the progeny through metabolic reprogramming in Drosophila.

中文翻译：

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卵母细胞代谢物是驱动后代代谢重编程的遗传因素

母亲的饮食会影响后代的发育，但对此负责的机制在很大程度上仍然未知。新的研究表明，卵母细胞代谢物，特别是 NAD+ 和甲基供体 S-腺苷甲硫氨酸，可以通过果蝇的代谢重编程介导母体营养压力对后代的影响。