Phytochemical investigation of the folk medicinal plant Argyreia acuta Lour. has led to the isolation of a pair of new 3-alkylated coumarin enantiomers, (±)-acutamarin [(±)-1] and 3 known structurally related coumarins (2-4), along with 4 known flavonoids (5-8). The structures of these compounds were elucidated on the basis of extensive spectroscopic (including one-dimensional and two-dimensional nuclear magnetic resonance) analyses and by comparison of their spectral data with those reported in the literature. The absolute configurations of ( − )-1 and ( + )-1 were proposed by comparison of experimental and calculated electronic circular dichroism data. Compounds 5 and 7 exhibited in vitro anti-inflammatory activity by inhibiting the production of nitric oxide with IC₅₀ values of 24.54 ± 0.36 μM and 10.60 ± 0.15 μM, respectively.

民间药用植物Argyreia acuta Lour的植物化学研究。已导致分离出一对新的 3-烷基化香豆素对映体，(±)-acutamarin [(±)- 1 ] 和 3 种已知结构相关的香豆素 ( 2-4 )，以及 4 种已知的黄酮类化合物 ( 5-8 ) . 这些化合物的结构是在广泛的光谱（包括一维和二维核磁共振）分析的基础上阐明的，并将其光谱数据与文献中报道的光谱数据进行比较。( - )- 1和( + )- 1的绝对构型是通过比较实验和计算电子圆二色性数据提出的。化合物5和7通过抑制一氧化氮的产生而表现出体外抗炎活性，IC ₅₀值分别为 24.54 ± 0.36 μM 和 10.60 ± 0.15 μM。