Abstract

From the Lasianthus bidoupensis stems, two new compounds, including one new 9,10-anthraquinone, lasibidoupin A (1), and one new 6,7-benzocoumarin, lasibidoupin B (2), together with one known compound, 11-O-methyldamnacanthol (3) were isolated using chromatographic method. Their structures were determined by extensive HRMS, and NMR assignments. Compound 3 was reported for the first time from this species. New compounds (1 & 2) were tested for the cytotoxicity against three human cancer cell lines (MCF-7, HeLa, and NCI-H460) by SRB assay. As results, 1 & 2 exhibited significant cytotoxic activity against all cancer cell lines (IC₅₀ ranged from 0.058 ± 0.003 to 0.177 ± 0.014 μM).

摘要

从Lasianthus bidoupensis茎中提取了两种新化合物，包括一种新的 9,10-蒽醌 lasibidoupin A ( 1 ) 和一种新的 6,7-苯并香豆素 lasibidoupin B ( 2 )，以及一种已知化合物 11- O -用色谱法分离了甲基damnacanthol ( 3 )。它们的结构由广泛的 HRMS 和 NMR 分配确定。化合物3为首次从该物种中报道。通过 SRB 测定法测试了新化合物（1和2）对三种人类癌细胞系（MCF-7、HeLa 和 NCI-H460）的细胞毒性。结果，1 & 2对所有癌细胞系均表现出显着的细胞毒活性（IC ₅₀范围为 0.058  ± 0.003 至 0.177 ± 0.014 μM）。