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Lasibidoupins A and B, two new compounds from the stems of Lasianthus bidoupensis V.S. Dang & Naiki
Natural Product Research ( IF 1.9 ) Pub Date : 2021-09-20 , DOI: 10.1080/14786419.2021.1979545
Nguyen Kim Tuyen Pham 1 , Thi Diem Huong Nguyen 1 , Thi Mong Cam Nguyen 1 , Gia Dinh Nguyen 1 , Cong Doan Huynh 2 , Thi Nga Vo 3 , Thi Quynh Trang Nguyen 1 , Thuc Huy Duong 4 , Van Son Dang 5 , Bui Linh Chi Huynh 6 , Thi Ngoc Mai Tran 7 , Tan Phat Nguyen 8, 9
Affiliation  

Abstract

From the Lasianthus bidoupensis stems, two new compounds, including one new 9,10-anthraquinone, lasibidoupin A (1), and one new 6,7-benzocoumarin, lasibidoupin B (2), together with one known compound, 11-O-methyldamnacanthol (3) were isolated using chromatographic method. Their structures were determined by extensive HRMS, and NMR assignments. Compound 3 was reported for the first time from this species. New compounds (1 & 2) were tested for the cytotoxicity against three human cancer cell lines (MCF-7, HeLa, and NCI-H460) by SRB assay. As results, 1 & 2 exhibited significant cytotoxic activity against all cancer cell lines (IC50 ranged from 0.058± 0.003 to 0.177 ± 0.014 μM).



中文翻译:

Lasibidoupins A 和 B,两种来自 Lasianthus bidoupensis VS Dang & Naiki 茎的新化合物

摘要

Lasianthus bidoupensis茎中提取了两种新化合物,包括一种新的 9,10-蒽醌 lasibidoupin A ( 1 ) 和一种新的 6,7-苯并香豆素 lasibidoupin B ( 2 ),以及一种已知化合物 11- O -用色谱法分离了甲基damnacanthol ( 3 )。它们的结构由广泛的 HRMS 和 NMR 分配确定。化合物3为首次从该物种中报道。通过 SRB 测定法测试了新化合物(12)对三种人类癌细胞系(MCF-7、HeLa 和 NCI-H460)的细胞毒性。结果,1 & 2对所有癌细胞系均表现出显着的细胞毒活性(IC 50范围为 0.058 ± 0.003 至 0.177 ± 0.014 μM)。

更新日期:2021-09-20
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