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The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer
International Journal of General Medicine ( IF 2.1 ) Pub Date : 2021-09-21 , DOI: 10.2147/ijgm.s323136 Wenhui Zhong 1 , Chunyu Zhou 2 , Lufei Chen 1 , Zhenna Wang 3 , Hongxing Lin 1 , Kunhai Wu 1 , Sujiao Zhang 4
International Journal of General Medicine ( IF 2.1 ) Pub Date : 2021-09-21 , DOI: 10.2147/ijgm.s323136 Wenhui Zhong 1 , Chunyu Zhou 2 , Lufei Chen 1 , Zhenna Wang 3 , Hongxing Lin 1 , Kunhai Wu 1 , Sujiao Zhang 4
Affiliation
Purpose: This study assessed the prognostic value of red blood cell distribution width (RDW) and cancer antigen 125 (CA125) in predicting the prognosis of endometrial cancer (EC) patients.
Patients and Methods: In this study, we included 525 patients with EC between January 2013 and January 2019. Demographic and clinical indicators were collected, and the receiver operating characteristics curve (ROC) and cutoff values were calculated between the early and advanced stages of EC. Independent risk factors associated with EC prognosis were assessed using Cox regression analyses and the Kaplan–Meier method.
Results: Compared to women in the early stage of EC, women with advanced stage had significantly elevated RDW coefficient of variation (RDW-CV) and CA125 levels and lower mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (both P < 0.05). Consequently, RDW-CV and CA125 were found to be independent risk factors for EC by using ROC curve and multivariate logistic regression analysis. The survival analysis curve was used to assess the diagnostic value of RDW-CV, CA125, and their combination in the prognosis of EC. The results showed that patients with high expression of RDW-CV and CA125 had worse overall survival than those with low expression. Moreover, multivariate Cox regression analysis indicated that RDW-CV+CA125=2 was an independent prognostic factor.
Conclusion: These findings suggest that CA125 combined with RDW-CV has a good prognostic value for EC. Thus, the RDW-CV+CA125 score is a promising prognostic marker for the clinical decision-making process regarding EC outcomes.
Keywords: CA125, RDW-CV, endometrial cancer, prognosis
中文翻译：
红细胞分布宽度变异系数结合癌抗原125预测子宫内膜癌术后总生存率
目的：本研究评估红细胞分布宽度（RDW）和癌抗原125（CA125）在预测子宫内膜癌（EC）患者预后中的预后价值。
患者和方法：在这项研究中，我们纳入了 2013 年 1 月至 2019 年 1 月期间的 525 名 EC 患者。收集了人口统计学和临床指标，计算了 EC 早期和晚期之间的受试者工作特征曲线（ROC）和截止值. 使用 Cox 回归分析和 Kaplan-Meier 方法评估与 EC 预后相关的独立危险因素。
结果：与EC早期女性相比，晚期女性RDW变异系数（RDW-CV）和CA125水平显着升高，平均红细胞体积（MCV）和平均红细胞血红蛋白（MCH）降低（均P < 0.05） . 因此，通过 ROC 曲线和多变量逻辑回归分析发现 RDW-CV 和 CA125 是 EC 的独立危险因素。生存分析曲线用于评估RDW-CV、CA125及其组合对EC预后的诊断价值。结果显示，RDW-CV和CA125高表达患者的总体生存率低于低表达患者。此外，多变量 Cox 回归分析表明 RDW-CV+CA125=2 是独立的预后因素。
结论：这些发现表明 CA125 联合 RDW-CV 对 EC 具有良好的预后价值。因此，RDW-CV+CA125 评分是有关 EC 结果的临床决策过程的有希望的预后标志物。
关键词： CA125，RDW-CV，子宫内膜癌，预后
更新日期：2021-09-20
Patients and Methods: In this study, we included 525 patients with EC between January 2013 and January 2019. Demographic and clinical indicators were collected, and the receiver operating characteristics curve (ROC) and cutoff values were calculated between the early and advanced stages of EC. Independent risk factors associated with EC prognosis were assessed using Cox regression analyses and the Kaplan–Meier method.
Results: Compared to women in the early stage of EC, women with advanced stage had significantly elevated RDW coefficient of variation (RDW-CV) and CA125 levels and lower mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) (both P < 0.05). Consequently, RDW-CV and CA125 were found to be independent risk factors for EC by using ROC curve and multivariate logistic regression analysis. The survival analysis curve was used to assess the diagnostic value of RDW-CV, CA125, and their combination in the prognosis of EC. The results showed that patients with high expression of RDW-CV and CA125 had worse overall survival than those with low expression. Moreover, multivariate Cox regression analysis indicated that RDW-CV+CA125=2 was an independent prognostic factor.
Conclusion: These findings suggest that CA125 combined with RDW-CV has a good prognostic value for EC. Thus, the RDW-CV+CA125 score is a promising prognostic marker for the clinical decision-making process regarding EC outcomes.
Keywords: CA125, RDW-CV, endometrial cancer, prognosis
中文翻译：
红细胞分布宽度变异系数结合癌抗原125预测子宫内膜癌术后总生存率
目的：本研究评估红细胞分布宽度（RDW）和癌抗原125（CA125）在预测子宫内膜癌（EC）患者预后中的预后价值。
患者和方法：在这项研究中，我们纳入了 2013 年 1 月至 2019 年 1 月期间的 525 名 EC 患者。收集了人口统计学和临床指标，计算了 EC 早期和晚期之间的受试者工作特征曲线（ROC）和截止值. 使用 Cox 回归分析和 Kaplan-Meier 方法评估与 EC 预后相关的独立危险因素。
结果：与EC早期女性相比，晚期女性RDW变异系数（RDW-CV）和CA125水平显着升高，平均红细胞体积（MCV）和平均红细胞血红蛋白（MCH）降低（均P < 0.05） . 因此，通过 ROC 曲线和多变量逻辑回归分析发现 RDW-CV 和 CA125 是 EC 的独立危险因素。生存分析曲线用于评估RDW-CV、CA125及其组合对EC预后的诊断价值。结果显示，RDW-CV和CA125高表达患者的总体生存率低于低表达患者。此外，多变量 Cox 回归分析表明 RDW-CV+CA125=2 是独立的预后因素。
结论：这些发现表明 CA125 联合 RDW-CV 对 EC 具有良好的预后价值。因此，RDW-CV+CA125 评分是有关 EC 结果的临床决策过程的有希望的预后标志物。
关键词： CA125，RDW-CV，子宫内膜癌，预后
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