Poly(2-alkyl-2-oxazoline)-Heparin Hydrogels—Expanding the Physicochemical Parameter Space of Biohybrid Materials,Advanced Healthcare Materials

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Poly(2-alkyl-2-oxazoline)-Heparin Hydrogels—Expanding the Physicochemical Parameter Space of Biohybrid Materials
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2021-09-20 , DOI: 10.1002/adhm.202101327
Dominik Hahn ₁ , Jannick M Sonntag _{2,

3} , Steffen Lück _{2,

3} , Manfred F Maitz ₁ , Uwe Freudenberg ₁ , Rainer Jordan _{2,

3} , Carsten Werner _{1,

4}

Affiliation

Poly(ethylene glycol) (PEG)-glycosaminoglycan (GAG) hydrogel networks are established as very versatile biomaterials. Herein, the synthetic gel component of the biohybrid materials is systematically varied by combining different poly(2-alkyl-2-oxazolines) (POx) with heparin applying a Michael-type addition crosslinking scheme: POx of gradated hydrophilicity and temperature-responsiveness provides polymer networks of distinctly different stiffness and swelling. Adjusting the mechanical properties and the GAG concentration of the gels to similar values allows for modulating the release of GAG-binding growth factors (VEGF165 and PDGF-BB) by the choice of the POx and its temperature-dependent conformation. Adsorption of fibronectin, growth of fibroblasts, and bacterial adhesion scale with the hydrophobicity of the gel-incorporated POx. In vitro hemocompatibility tests with freshly drawn human whole blood show advantages of POx-based gels compared to the PEG-based reference materials. Biohybrid POx hydrogels can therefore enable biomedical technologies requiring GAG-based materials with customized and switchable physicochemical characteristics.

中文翻译：

聚（2-烷基-2-恶唑啉）-肝素水凝胶——扩展生物杂化材料的理化参数空间

聚（乙二醇）（PEG）-糖胺聚糖（GAG）水凝胶网络被确立为非常通用的生物材料。在此，生物杂化材料的合成凝胶成分通过将不同的聚（2-烷基-2-恶唑啉）（POx）与肝素应用迈克尔型加成交联方案相结合而系统地改变：具有渐变亲水性和温度响应性的 POx 提供聚合物具有明显不同刚度和膨胀的网络。将凝胶的机械性能和 GAG 浓度调整到类似的值，可以通过选择 POx 及其温度依赖性构象来调节 GAG 结合生长因子（VEGF165 和 PDGF-BB）的释放。纤连蛋白的吸附、成纤维细胞的生长和细菌粘附规模与凝胶结合 POx 的疏水性。使用新鲜抽取的人全血进行的体外血液相容性测试表明，与基于 PEG 的参考材料相比，基于 POx 的凝胶具有优势。因此，生物混合 POx 水凝胶可以实现需要具有定制和可切换物理化学特性的 GAG 材料的生物医学技术。

更新日期：2021-11-17

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