The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that have evolved from the clinical trial experience of the Immune Tolerance Network, with an emphasis on lessons learned from the innovative mechanistic studies conducted for these trials and new strategies under development for induction of tolerance.

中文翻译：

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建立免疫介导疾病耐受性的方法

开发恢复免疫耐受的合理方法需要一种迭代方法，该方法建立在过去的成功基础上，并利用对免疫介导病理学的新机制见解。本文将回顾从免疫耐受网络的临床试验经验演变而来的概念，重点是从为这些试验进行的创新机制研究中吸取的经验教训以及正在开发的诱导耐受的新策略。