The aim of this study was to assess the influence of physical activity in inflammatory, biochemical and endocrine parameters of middle-aged and elderly men with Systemic Arterial Hypertension (SAH) and Type 2 Diabetes Mellitus (T2DM). The assessment was comprised by 77 male volunteers aged between 45 and 59 years old (middle-aged men) or 60 to 86 years old (elderly men), diagnosed with SAH and T2DM, assisted by Family Health Units in Vitória da Conquista, Bahia, Brazil. According to age and lifestyle (sedentary or practicing physical activity), these men were classified as middle-aged sedentary men, middle-aged physically active men, elderly sedentary men, or elderly physically active men. It was noticed that active elderly people with SAH and T2DM had a better inflammatory balance than sedentary middle-aged men, through the evaluation of the relationship between the cytokines IL-10/TNF-α, IL-10/IL-17A and IL-10/IFN-γ. Moreover, in the extended correlation analysis, a greater global balance was observed among anthropometric, blood pressure, biochemical and cytokine parameters. Physical activity beneficially modulates aging-related disease risk factors even in elderly individuals.

本研究的目的是评估体力活动对患有系统性动脉高血压 (SAH) 和 2 型糖尿病 (T2DM) 的中老年男性的炎症、生化和内分泌参数的影响。该评估由 77 名年龄在 45 至 59 岁（中年男性）或 60 至 86 岁（老年男性）之间的男性志愿者组成，他们被诊断为 SAH 和 T2DM，由巴伊亚州维多利亚达康奎斯塔的家庭健康部门提供协助，巴西。根据年龄和生活方式（久坐或锻炼身体活动），这些男性被分为中年久坐男性、中年身体活跃男性、老年久坐男性或老年身体活跃男性。值得注意的是，患有 SAH 和 T2DM 的活跃老年人比久坐的中年男性具有更好的炎症平衡，通过评估细胞因子IL-10/TNF-α、IL-10/IL-17A和IL-10/IFN-γ之间的关系。此外，在扩展的相关分析中，在人体测量学、血压、生化和细胞因子参数之间观察到了更大的整体平衡。即使在老年人中，体育活动也能有益地调节与衰老相关的疾病风险因素。