Background

 Traumatic brain injury (TBI) is one of the main causes of death and disability among the elderly patient population. This study aimed to assess the predictors of in-hospital mortality of elderly patients with moderate to severe TBI who presented during the Coronavirus disease 2019 (COVID-19) pandemic.

Methods

In this retrospective analytical study, all elderly patients with moderate to severe TBI who were referred to our center between March 2nd, 2020 to August 1st, 2020 were investigated and compared against the TBI patients receiving treatment during the same time period within the year 2019. Patients were followed until discharge from the hospital or death. The demographic, clinical, radiological, and laboratory test data were evaluated. Data were analyzed using SPSS-21 software.

Findings

In this study, 359 elderly patients were evaluated (n = 162, Post-COVID-19). Fifty-four patients of the cohort had COVID-19 disease with a mortality rate was 33.3%. The patients with COVID-19 were 5.45 times more likely to expire before discharge (P < 0.001) than the TBI patients who were not COVID-19 positive. Other variables such as hypotension (OR, 4.57P < 0.001), hyperglycemia (OR, 2.39, P = 0.002), and use of anticoagulant drugs (OR, 2.41P = 0.001) were also associated with in-hospital death. According to the binary logistic regression analysis Age (OR, 1.72; 95% CI: 1.26–2.18; P = 0.033), Coronavirus infection (OR, 2.21; 95% CI: 1.83–2.92; P = 0.011) and Glasgow Coma Scale (GCS) (OR, 3.11; 95% CI: 2.12–4.53; P < 0.001) were independent risk factors correlated with increased risk of in-hospital mortality of elderly patients with moderate to severe TBI.

Conclusion

Our results showed that Coronavirus infection could increase the risk of in-hospital mortality of elderly patients with moderate to severe TBI significantly.

中文翻译：

---

2019 冠状病毒病 (COVID-19) 对中重度颅脑损伤老年患者院内死亡率的显着影响：一项回顾性观察研究

背景

 创伤性脑损伤 (TBI) 是导致老年患者死亡和残疾的主要原因之一。本研究旨在评估在 2019 年冠状病毒病 (COVID-19) 大流行期间出现的中重度 TBI 老年患者院内死亡率的预测因素。

方法

在这项回顾性分析研究中，对2020年3月2日至2020年8月1日期间转诊到我中心的所有中重度TBI老年患者进行了调查，并与2019年同期接受治疗的TBI患者进行了比较。随访患者直至出院或死亡。评估了人口统计学、临床、放射学和实验室测试数据。数据采用SPSS-21软件进行分析。

发现

在这项研究中，评估了 359 名老年患者（n  = 162，COVID-19 后）。该队列中有 54 名患者患有 COVID-19，死亡率为 33.3%。COVID-19 患者出院前死亡的可能性是非 COVID-19 阳性 TBI 患者的 5.45 倍（P < 0.001）。其他变量，如低血压（OR，4.57P < 0.001）、高血糖（OR，2.39，P = 0.002）和抗凝药物的使用（OR，2.41P = 0.001）也与院内死亡有关。 根据二元逻辑回归分析年龄（OR，1.72；95% CI：1.26–2.18；P = 0.033）、冠状病毒感染（OR，2.21；95% CI：1.83–2.92；P = 0.011）和格拉斯哥昏迷量表（ GCS）（OR，3.11；95% CI：2.12–4.53；P < 0.001）是与中重度 TBI 老年患者院内死亡率增加相关的独立危险因素。

结论

我们的研究结果表明，冠状病毒感染可显着增加老年中重度 TBI 患者的院内死亡风险。