A fast, efficient, and simple method for fabricating a pH-responsive gating membrane is discussed in this paper. 248 nm KrF excimer laser was used to fabricate base polyimide (PI) membrane and in the second stage, i.e., grafting. We have already studied the effect of laser parameters on grafting. This paper is an extension of our previous study. In this paper we reported the effects of solution parameters, i.e., concentration of monomer and crosslinker on water permeability, and diffusion across the membrane was studied. Polyacrylic acid (PAAc) was used to make membrane stimuli responsive. Caffeine was used as a model drug molecule for diffusion studies. Qualitative and quantitative analyses were carried out using ATR-FTIR and TGA methods. With the help of appropriate tuning of concentration parameters and laser parameter - the number of pulses, water permeability up to 6 order of magnitude could be achieved. We have also successfully demonstrated that controlled release of solute over a larger period could be achieved using the fabrication technique we proposed. This technique can be a powerful tool to develop responsive membranes for medical applications as the fabrication process does not involve any organic solvent.

本文讨论了一种快速、高效、简单的 pH 响应门控膜的制备方法。248 nm KrF 准分子激光器用于制造基础聚酰亚胺 (PI) 膜和第二阶段，即接枝。我们已经研究了激光参数对嫁接的影响。本文是我们之前研究的延伸。在本文中，我们报告了溶液参数的影响，即单体和交联剂的浓度对水渗透性的影响，并研究了跨膜扩散。聚丙烯酸 (PAAc) 用于使膜刺激响应。咖啡因被用作扩散研究的模型药物分子。使用 ATR-FTIR 和 TGA 方法进行定性和定量分析。借助适当调整浓度参数和激光参数——脉冲数，可实现高达 6 个数量级的透水性。我们还成功地证明了使用我们提出的制造技术可以在更长的时间内实现溶质的受控释放。由于制造过程不涉及任何有机溶剂，因此该技术可以成为开发用于医疗应用的响应膜的强大工具。