There is increasing concern about cardiovascular disease (CVD) after breast cancer (BC). The aim of this study was to estimate the prevalence of different types of CVD in women diagnosed with BC compared to cancer-free controls as well as the incidence of CVD after BC diagnosis. We performed a cohort study based on data from national registries covering the entire Danish population. We followed 16,505 cancer-naïve BC patients diagnosed from 2003 to 2007 5 years before and up to 10 years after BC diagnosis compared to 165,042 cancer-free controls. We found that 15.6% of BC patients were registered with at least one CVD diagnosis in hospital records before BC diagnosis. Overall, BC patients and controls were similar with regard to CVD comorbidity before BC diagnosis. After BC diagnosis, the incidence of all CVD diagnoses combined was significantly higher in BC patients than controls up to approximately 6 years after the index date (BC diagnosis). After 10 years, 28% of both BC patients and controls (without any CVD diagnosis up to 5 years before the index date) had at least one CVD diagnosis according to hospital records. However, the incidence of heart failure, thrombophlebitis/thrombosis and pulmonary heart disease including pulmonary embolism remained higher in BC patients than controls during the entire 10-year follow-up period. After 10 years, 2.7% of BC patients compared to 2.5% of controls were diagnosed with heart failure, 2.7% of BC patients compared to 1.5% of controls were diagnosed with thrombophlebitis/thrombosis, and 1.5% of BC patients compared to 1.0% of controls were diagnosed with pulmonary heart disease according to hospital records. Furthermore, we found that the risk of heart failure and thrombophlebitis/thrombosis was higher after chemotherapy. Focus on CVD in BC patients is important to ensure optimum treatment with regard to BC as well as possible CVD. Strategies to minimise and manage the increased risk of heart failure, thrombophlebitis/thrombosis and pulmonary heart disease including pulmonary embolism in BC patients are especially important.

中文翻译：

---

乳腺癌女性的心血管疾病——一项全国性队列研究

人们越来越关注乳腺癌 (BC) 之后的心血管疾病 (CVD)。本研究的目的是估计诊断为 BC 的女性与无癌对照组相比不同类型 CVD 的患病率，以及 BC 诊断后 CVD 的发生率。我们根据涵盖整个丹麦人口的国家登记处的数据进行了一项队列研究。我们对 2003 年至 2007 年在 BC 诊断前 5 年和 10 年后诊断出的 16,505 名未患癌症的 BC 患者进行了随访，与 165,042 名无癌症对照者进行了比较。我们发现 15.6% 的 BC 患者在 BC 诊断之前在医院记录中至少有一项 CVD 诊断。总体而言，BC 患者和对照组在 BC 诊断前的 CVD 合并症方面相似。BC确诊后，在索引日期（BC 诊断）后约 6 年，所有 CVD 诊断的发生率在 BC 患者中显着高于对照组。10 年后，根据医院记录，28% 的 BC 患者和对照（在索引日期前 5 年内没有任何 CVD 诊断）至少有一次 CVD 诊断。然而，在整个 10 年的随访期间，BC 患者的心力衰竭、血栓性静脉炎/血栓形成和肺心病（包括肺栓塞）的发生率仍然高于对照组。10 年后，2.7% 的 BC 患者与对照组的 2.5% 相比被诊断为心力衰竭，2.7% 的 BC 患者与对照组的 1.5% 相比被诊断为血栓性静脉炎/血栓形成，1.5% 的 BC 患者与 1 相比。根据医院记录，0% 的对照被诊断出患有肺心病。此外，我们发现化疗后心力衰竭和血栓性静脉炎/血栓形成的风险更高。关注 BC 患者的 CVD 对确保对 BC 和可能的 CVD 进行最佳治疗很重要。减少和管理心力衰竭、血栓性静脉炎/血栓形成和肺心病（包括 BC 患者的肺栓塞）风险增加的策略尤为重要。