COVER ILLUSTRATION In our study, we explored the change of neuron coupling relationship between oxygen and glucose metabolism (lower left) among normal controls, preclinical Alzheimer's disease (preAD) and cognitive impairments (CI) subjects (upper right). The oxygen metabolism was represented by the fractional amplitude of low-frequency fluctuations (fALFF) and the regional homogeneity (ReHo) from resting-state functional magnetic resonance imaging (rs-fMRI) (upper left). The glucose metabolism was the standard uptake value ratio (SUVR) calculated from [18F] fluorodeoxyglucose positron emission tomography (18F-FDG PET) (lower right). Our results indicated the coupling relationship based on ReHo and SUVR changed during the preAD stage in the default mode network (DMN) area, and it could be a novel potential biomarker for PreAD (center).

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封面插图在我们的研究中，我们探讨了正常对照、临床前阿尔茨海默病 (preAD) 和认知障碍 (CI) 受试者（右上）之间氧和糖代谢（左下）之间神经元耦合关系的变化。氧代谢由来自静息态功能磁共振成像 (rs-fMRI) 的低频波动幅度 (fALFF) 和区域同质性 (ReHo) 表示（左上）。葡萄糖代谢是从[18F]氟脱氧葡萄糖正电子发射断层扫描（18F-FDG PET）（右下）计算的标准摄取值比（SUVR）。我们的结果表明，基于 ReHo 和 SUVR 的耦合关系在默认模式网络 (DMN) 区域的 preAD 阶段发生了变化，它可能是 PreAD（中心）的新型潜在生物标志物。