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Pathogens and extracellular vesicles: New paths and challenges to understanding and treating diseases. Editorial opinion
Molecular Immunology ( IF 3.2 ) Pub Date : 2021-09-17 , DOI: 10.1016/j.molimm.2021.09.006
Marcel I Ramirez 1 , Antonio Marcilla 2
Affiliation  

Extracellular vesicles (EVs) have been described in all eukaryotic and prokaryotic cells as released membranous structures loaded with biomolecules including nucleic acids, glycoconjugates, lipids and proteins. Two main groups of vesicles with different biogenesis and size are considered to be the most predominant, Exosomes (30–100 nm) originating from multivesicular bodies, and microvesículas (100–1000 nm) originating from plasma membrane. EVs participate in cellular communication between different organisms and can alter neighbour cells, participating in physiological and pathophysiological processes. In this issue, eleven reviews summarize the current knowledge in the characterization of EVs participating in the pathogenic-host interaction including protozoa, helminths, bacteria, fungi and viruses (Montaño et al., 2021; Palacios et al., 2021; Rossi et al., 2021; Sabatke et al., 2021; Cucher et al., 2021; Gilmore W et al., 2021; Sánchez-López et al., 2021; Dong et al., 2021; Drurey C and Mayzels R.M., 2021; Macedo-Da Silva J et al., 2021; Piffer, A. C et al., 2021).



中文翻译:

病原体和细胞外囊泡:理解和治疗疾病的新途径和挑战。编辑意见

细胞外囊泡 (EV) 在所有真核和原核细胞中都被描述为释放的膜结构,其装载有生物分子,包括核酸、糖缀合物、脂质和蛋白质。具有不同生物发生和大小的两类主要囊泡被认为是最主要的,来自多泡体的外泌体(30-100 nm)和来自质膜的微泡(100-1000 nm)。EVs 参与不同生物体之间的细胞通讯,可以改变相邻细胞,参与生理和病理生理过程。在本期中,11 篇评论总结了参与病原-宿主相互作用的 EV 表征的当前知识,包括原生动物、蠕虫、细菌、真菌和病毒(Montaño 等,2021;Palacios 等,2021;罗西等人,2021 年;Sabatke 等人,2021 年;Cucher 等人,2021 年;吉尔摩 W 等人,2021 年;Sánchez-López 等人,2021 年;董等人,2021;Drurey C 和 Mayzels RM,2021 年;Macedo-Da Silva J 等人,2021 年;Piffer, A. C 等人,2021 年)。

更新日期:2021-09-19
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