Over the past decade, tremendous progress has been made in systems biology-based approaches to studying immunity to viral infections and responses to vaccines. These approaches that integrate multiple facets of the immune response, including transcriptomics, serology and immune functions, are now being applied to understand correlates of protective immunity against hepatitis C virus (HCV) infection and to inform vaccine development. This review focuses on recent progress in understanding immunity to HCV using systems biology, specifically transcriptomic and epigenetic studies. It also examines proposed strategies moving forward towards an integrated systems immunology approach for predicting and evaluating the efficacy of the next generation of HCV vaccines.

中文翻译：

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迈向系统免疫学方法以了解针对 HCV 的保护性免疫的相关性

在过去的十年中，基于系统生物学的方法在研究对病毒感染的免疫力和对疫苗的反应方面取得了巨大进展。这些方法整合了免疫反应的多个方面，包括转录组学、血清学和免疫功能，现在正被用于了解针对丙型肝炎病毒 (HCV) 感染的保护性免疫的相关性，并为疫苗开发提供信息。这篇综述着重于使用系统生物学，特别是转录组学和表观遗传学研究来了解对 HCV 免疫的最新进展。它还研究了向综合系统免疫学方法发展的拟议战略，以预测和评估下一代 HCV 疫苗的功效。