Photoactivated chemotherapy (PACT) is a novel cancer treatment method that has drawn increasing attention due to its high selectivity and low side effects by spatio-temporal control of irradiation. Compared with photodynamic therapy (PDT), oxygen-independent PACT is more suitable for treating hypoxic tumors. By finely tuning ligand structures and coordination configurations, many Ru(II) complexes can undergo photoinduced ligand dissociation, and the resulting Ru(II) aqua species and/or free ligands may have anticancer activity, showing their potential as PACT agents. In this mini-review, we summarized the progress in Ru(II)-based PACT agents, as well as challenges that researchers in this field still face.

中文翻译：

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钌基光激活化疗药物的研制


光激活化疗（PACT）是一种新型的癌症治疗方法，通过时空控制照射而具有高选择性和低副作用，受到越来越多的关注。与光动力疗法（PDT）相比，不依赖氧的PACT更适合治疗缺氧肿瘤。通过精细调节配体结构和配位构型，许多 Ru(II) 配合物可以发生光诱导配体解离，所得的 Ru(II) 水合物和/或游离配体可能具有抗癌活性，显示出其作为 PACT 制剂的潜力。在这篇小综述中，我们总结了基于 Ru(II) 的 PACT 药物的进展，以及该领域研究人员仍然面临的挑战。