This study aims to investigate possible different outcomes in the inpatient treatment of anorexia nervosa (AN) related to different timings of psychopharmacological and nutritional interventions. A retrospective observational study was conducted, involving young patients hospitalized for AN, treated with naso-gastric tube feeding (NGT). Participants were divided into five groups according to early (0–7 days) or late (8+ days) introduction of atypical antipsychotics (AAP) and NGT: early AAP-early NGT (EE), early AAP-late NGT (EL), late AAP-early NGT (LE), late AAP-late NGT (LL) and a control group treated with NGT only (NGT). Concurrent clinical and treatment variables were analyzed. AN psychopathology was measured with the Eating Disorder Inventory-3 (EDI-3) EDRC score. Outcomes were assessed as admission-discharge body-mass index (BMI) improvement and length of hospital stay (LOS). Contributions of variables related to outcomes were assessed with multifactorial-analyses of variance (MANOVA). Seventy-nine patients were enrolled in the study. LOS was different among treatment groups (F (4, 75) = 5.993, p < 0.001), and EE patients showed lower LOS than LE (p < 0.001) and LL (p = 0.025) patients. BMI improvement was not significantly different among treatment groups but correlated negatively with age (F (1, 72) = 10.130, p = 0.002), and admission BMI (F (1, 72) = 14.681, p < 0.001). In conclusion, patients treated with early AAP and early NGT showed lower LOS than those treated with late AAP. Prognostic treatment variables should be investigated in wider samples.

中文翻译：

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神经性厌食症住院治疗中精神药理学和营养干预的时机：一项观察性研究

本研究旨在调查与精神药理学和营养干预的不同时间相关的神经性厌食症 (AN) 住院治疗中可能出现的不同结果。进行了一项回顾性观察研究，涉及因 AN 住院并接受鼻胃管喂养 (NGT) 治疗的年轻患者。根据早期（0-7 天）或晚期（8+ 天）引入非典型抗精神病药 (AAP) 和 NGT 将参与者分为五组：早期 AAP-早期 NGT (EE)、早期 AAP-晚期 NGT (EL)、晚期 AAP-早期 NGT (LE)、晚期 AAP-晚期 NGT (LL) 和仅用 NGT 治疗的对照组 (NGT)。分析了同时发生的临床和治疗变量。AN 精神病理学通过饮食失调量表 3 (EDI-3) EDRC 评分进行测量。结果评估为入院-出院体重指数（BMI）改善和住院时间（LOS）。使用多因素方差分析 (MANOVA) 评估与结果相关的变量的贡献。79 名患者参加了这项研究。治疗组之间的 LOS 不同（F (4, 75) = 5.993，p < 0.001)，EE 患者的 LOS 低于 LE ( p < 0.001) 和 LL ( p = 0.025) 患者。BMI 改善在治疗组之间没有显着差异，但与年龄 (F (1, 72) = 10.130, p = 0.002) 和入院 BMI (F (1, 72) = 14.681, p < 0.001)呈负相关。总之，接受早期 AAP 和早期 NGT 治疗的患者的 LOS 低于接受晚期 AAP 治疗的患者。应在更广泛的样本中研究预后治疗变量。