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Large scale production of 64Cu and 67Cu via the 64Zn(n, p)64Cu and 68Zn(n, np/d)67Cu reactions using accelerator neutrons
Journal of Radioanalytical and Nuclear Chemistry ( IF 1.5 ) Pub Date : 2021-09-18 , DOI: 10.1007/s10967-021-07987-3
Masako Kawabata 1, 2 , Shoji Motoishi 1, 2 , Akio Ohta 1, 2 , Arata Motomura 1, 2 , Yasuki Nagai 1, 2 , Hideya Saeki 2, 3 , Kazuaki Tsukada 2, 4 , Kazuyuki Hashimoto 2 , Shintaro Hashimoto 5 , Nobuyuki Iwamoto 5
Affiliation  

Both 64Cu and 67Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable 64Cu and 67Cu yields were estimated by experimental based numerical simulations using 100 g of enriched 64Zn and 68Zn, respectively, and elevated neutron fluxes from 40 MeV, 2 mA deuterons. A combined thermal- and resin-separation method was developed to isolate 64Cu and 67Cu from zinc, resulting in 73% separation efficiency and 97% zinc recovery. Such methods can provide large scale production of 64Cu and 67Cu for clinical applications.



中文翻译:

使用加速器中子通过 64Zn(n, p)64Cu 和 68Zn(n, np/d)67Cu 反应大规模生产 64Cu 和 67Cu

这两个64铜和67铜是有前途的核医学的放射性核素。这些放射性核素的产量通过用加速器中子照射 55.4 克天然锌进行量化。临床上合适的64 Cu 和67 Cu 产率通过基于实验的数值模拟分别使用 100 g 富集的64 Zn 和68 Zn 以及来自 40 MeV、2 mA 氘核的中子通量进行估算。开发了一种结合热分离和树脂分离的方法,从锌中分离出64 Cu 和67 Cu,实现了 73% 的分离效率和 97% 的锌回收率。这样的方法可以提供64用于临床应用的Cu 和67 Cu。

更新日期:2021-09-19
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