Introduction

Atrial fibrillation (AF) represents the most common cardiac arrhythmia in daily clinical practice and substantially impacts affected patients by elevation of both morbidity and mortality. Previous investigations proved that inflammatory processes are closely linked to this multifactorial pathogenesis—especially autoreactive CD4⁺CD28^null T cells received in-depth attention.

Purpose

Consequently, a potential pathophysiological pathway of the impact of CD4⁺CD28null T lymphocytes on the development and progression AF can be outlined.

Conclusion

Considering the available data in the literature, it needs to be assumed that CD4⁺CD28^null T lymphocytes are mainly involved in the development of AF and disease progression. Of utmost importance, it can be considered as the result of a T-cell-mediated auto-immune reaction among myocardial tissue. However, mechanisms which recruit CD4⁺CD28^null cells in cardiac tissue remain unclear and need further investigation.

中文翻译：

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CD4+CD28null T淋巴细胞对心房颤动的影响：一个潜在的病理生理途径

介绍

心房颤动 (AF) 是日常临床实践中最常见的心律失常，并通过发病率和死亡率的升高对患者产生重大影响。先前的研究证明，炎症过程与这种多因素发病机制密切相关——尤其是自身反应性 CD4 ⁺ CD28^无效T 细胞受到了深入关注。

目的

因此，可以概述CD4 ⁺ CD28null T 淋巴细胞对 AF 发展和进展的影响的潜在病理生理学途径。

结论

考虑到文献中的可用数据，需要假设 CD4 ⁺ CD28^无效T 淋巴细胞主要参与 AF 的发展和疾病进展。最重要的是，它可以被认为是心肌组织之间 T 细胞介导的自身免疫反应的结果。然而，在心脏组织中募集 CD4 ⁺ CD28^无效细胞的机制仍不清楚，需要进一步研究。