The astroglial enzyme glutamine synthetase (GS) is deficient in small loci in the brain in adult patients with different types of focal epilepsy; however, the role of this deficiency in the pathogenesis of epilepsy has been difficult to assess due to a lack of sufficiently sensitive and specific animal models. The aim of this study was to develop an in vivo approach for precise and specific deletions of the GS gene in the postnatal brain.

中文翻译：

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出生后大脑中星形胶质细胞谷氨酰胺合成酶缺乏的小基因座导致癫痫发作和功能连接受损

星形胶质酶谷氨酰胺合成酶 (GS) 在患有不同类型局灶性癫痫的成年患者大脑中的小位点缺乏；然而，由于缺乏足够敏感和特异性的动物模型，这种缺陷在癫痫发病机制中的作用一直难以评估。本研究的目的是开发一种体内方法，用于精确和特异性地删除出生后大脑中的 GS 基因。