The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or detrimental consequences. This dichotomy is influenced by both the genetics and the environment. Depending on which way prevails in an individual, the outcome may be healthy longevity or pathological aging burdened with aging-related diseases. The concept of inflammaging has also revealed the complex, systemic nature of aging. Thus, this conceptualization opens the way to consider age-related processes in their complexity, meaning that not only the process but also all counter-processes should be considered. It has also opened the way to add new concepts to the original one, leading to better understanding of the nature of inflammaging and of aging itself. Finally, it showed the way towards potential multimodal interventions involving a holistic approach to optimize the aging process towards a healthy longevity.

炎症概念由 Franceschi 教授于 2000 年提出。这是对终生压力反应的免疫变化的进化概念化，或者说是革命性的概念化。这种概念化允许将终生促炎过程视为一种适应，最终可能导致有益或有害的后果。这种二分法受到遗传和环境的影响。根据个体的流行方式，结果可能是健康长寿或因衰老相关疾病而负担沉重的病态衰老。炎症的概念也揭示了衰老的复杂、系统性。因此，这种概念化为考虑与年龄相关的过程的复杂性开辟了道路，这意味着不仅应该考虑过程，还应该考虑所有的反过程。它还开辟了向原始概念添加新概念的途径，从而更好地理解炎症和衰老本身的本质。最后，它展示了潜在的多模式干预措施，涉及一种优化衰老过程以实现健康长寿的整体方法。