Polydopamine Nanobottles with Photothermal Capability for Controlled Release and Related Applications,Advanced Materials

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Polydopamine Nanobottles with Photothermal Capability for Controlled Release and Related Applications
Advanced Materials ( IF 27.4 ) Pub Date : 2021-09-17 , DOI: 10.1002/adma.202104729
Jichuan Qiu ₁ , Yifeng Shi ₂ , Younan Xia _{1,

2,

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Affiliation

Nanobottles refer to colloidal particles featuring a hollow body connected to a single opening on the surface. This unique feature makes them ideal carriers for the encapsulation and controlled release of various types of cargos. Here a facile route to the fabrication of uniform nanobottles made of polydopamine by leveraging swelling-induced pressure is reported. When polystyrene spheres are coated with polydopamine and then incubated with a toluene/water emulsion, the polystyrene will be swollen to automatically poke a single hole in the shell because of the pressure inside the shell. After quenching the swelling with ethanol and then removing all the polystyrene with tetrahydrofuran, polydopamine nanobottles are obtained. The dimensions of the hollow body are determined by the polystyrene template, while the size of the opening can be tuned by varying the shell thickness. Through the opening, different types of cargos, including small molecules and biomacromolecules, can be easily loaded with a thermoresponsive material into the cavity. The cargos can be released in a controllable manner through direct heating or polydopamine-enabled photothermal heating. In a proof-of-concept experiment, the polydopamine nanobottles are used for temperature-controlled release of thrombin to trigger the formation of fibrin gels in situ.

中文翻译：

用于控释和相关应用的具有光热能力的聚多巴胺纳米瓶

纳米瓶是指具有连接到表面上的单个开口的中空体的胶体颗粒。这种独特的特性使它们成为封装和控制释放各种类型货物的理想载体。本文报道了一种利用溶胀引起的压力来制造由聚多巴胺制成的均匀纳米瓶的简便途径。当聚苯乙烯球涂有聚多巴胺，然后与甲苯/水乳液一起孵育时，由于壳内的压力，聚苯乙烯会膨胀以自动在壳上戳出一个孔。用乙醇淬灭溶胀，然后用四氢呋喃去除所有的聚苯乙烯，得到聚多巴胺纳米瓶。空心体的尺寸由聚苯乙烯模板决定，而开口的大小可以通过改变外壳厚度来调整。通过开口，不同类型的货物，包括小分子和生物大分子，可以很容易地与热响应材料一起装载到空腔中。货物可以通过直接加热或聚多巴胺光热加热以可控方式释放。在概念验证实验中，聚多巴胺纳米瓶用于凝血酶的温度控制释放，以触发原位纤维蛋白凝胶的形成。

更新日期：2021-11-09

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