Several studies on the potential adverse effects of aluminum oxide nanoparticles (Al2O3NPs) have reported conflicting results. The present study investigated the potential adverse effects of Al2O3NPs in Sprague-Dawley rats following 28-day repeated oral administration. In addition, we aimed to determine the target organ and no-observed-adverse-effect level (NOAEL) of Al2O3NPs. Al2O3NPs was administered once daily by gavage to male and female rats at dose levels of 0, 500, and 1000 mg/kg/day for 28 days. There were no treatment-related adverse effects as indicated by the clinical signs, body weight, food consumption, urinalysis, ophthalmology, hematology, serum biochemistry, gross pathology, organ weight, and histopathology at all the tested doses. Under the experimental conditions of the present study, 28-day repeated oral administration of Al2O3NPs at doses of up to 1000 mg/kg/day did not induce any treatment-related systemic toxicity in male and female rats. The NOAEL of Al2O3NPs was set at 1000 mg/kg/day in both male and female rats and no target organs were identified.

中文翻译：

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28 天重复口服给药后大鼠中氧化铝纳米颗粒的亚慢性毒性评价。

几项关于氧化铝纳米粒子 (Al2O3NPs) 潜在不利影响的研究报告了相互矛盾的结果。本研究调查了 Al2O3NPs 对 Sprague-Dawley 大鼠 28 天重复口服给药后的潜在不良影响。此外，我们旨在确定 Al2O3NPs 的靶器官和未观察到的不良反应水平 (NOAEL)。Al2O3NPs 以 0、500 和 1000 mg/kg/天的剂量水平每天通过管饲法对雄性和雌性大鼠施用一次，持续 28 天。在所有测试剂量下，如临床体征、体重、食物消耗、尿液分析、眼科、血液学、血清生化、大体病理学、器官重量和组织病理学所示，没有与治疗相关的不良反应。在本研究的实验条件下，28 天重复口服给予剂量高达 1000 mg/kg/天的 Al2O3NPs 在雄性和雌性大鼠中没有引起任何与治疗相关的全身毒性。在雄性和雌性大鼠中，Al2O3NPs 的 NOAEL 均设定为 1000 mg/kg/天，未发现靶器官。