Throughout the history of medicine, scientists and clinicians have observed unanticipated drug effects leading at times to an entirely new use for a drug class, and other times eliminating them from practice. The sodium-glucose cotransporter-2 (SGLT2) inhibitors are one such class of drugs. These agents were initially studied as diabetic agents and their unanticipated and significant cardiovascular benefit has now created a new class of drugs for an entirely new population. Here we review the pleiotropic cardiovascular effects of SGLT2 inhibitors, the potential mechanisms of action, side effect profile and future directions.

中文翻译：

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钠 - 葡萄糖协同转运蛋白 2 抑制剂的多效心血管作用。

纵观医学历史，科学家和临床医生观察到意想不到的药物效应，有时会导致药物类别的全新用途，有时会从实践中消除它们。钠-葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂就是这样一类药物。这些药物最初是作为糖尿病药物进行研究的，它们出乎意料的显着心血管益处现在已经为全新的人群创造了一类新的药物。在这里，我们回顾了 SGLT2 抑制剂的多效心血管作用、潜在的作用机制、副作用概况和未来方向。